Effectiveness of a cardiac rehabilitation program on biomechanical, imaging, and physiological biomarkers in elderly patients with heart failure with preserved ejection fraction (HFpEF): FUNNEL + study protocol

Simple item page
dc.contributor.authorCuesta-Vargas, Antonio
dc.contributor.authorFuentes-Abolafio, Iván José
dc.contributor.authorGarcía-Conejo, Celia
dc.contributor.authorDíaz-Balboa, Estibaliz
dc.contributor.authorTrinidad Fernández, Manuel
dc.contributor.authorGutiérrez-Sánchez, Daniel
dc.contributor.authorEscriche-Escuder, Adrián
dc.contributor.authorCobos-Palacios, Lidia
dc.contributor.authorLópez-Sampalo, Almudena
dc.contributor.authorPérez-Ruíz, Jose María
dc.contributor.authorRoldán-Jiménez, Cristina
dc.contributor.authorPérez-Velasco, Miguel Angel
dc.contributor.authorMora-Robles, Javier
dc.contributor.authorLópez Carmona, Carmen
dc.contributor.authorPérez-Cruzado, David Francisco
dc.contributor.authorMartín-Martín, Jaime
dc.contributor.authorPérez-Belmonte, Luis Miguel
dc.date.accessioned2024-09-20T11:58:28Z
dc.date.available2024-09-20T11:58:28Z
dc.date.issued2023-11
dc.departamentoSalud Pública y Psiquiatría
dc.descriptionBackground: Patients with heart failure with preserved ejection fraction (HFpEF) have a low functional status, which in turn is a risk factor for hospital admission and an important predictor of survival in HFpEF. HFpFE is a heterogeneous syndrome and recent studies have suggested an important role for careful, pathophysiological-based phenotyping to improve patient characterization. Cardiac rehabilitation has proven to be a useful tool in the framework of secondary prevention in patients with HFpEF. Facilitating decision-making and implementing cardiac rehabilitation programs is a challenge in public health systems for HFpEF management. The FUNNEL + study proposes to evaluate the efficacy of an exercise and education-based cardiac rehabilitation program on biomechanical, physiological, and imaging biomarkers in patients with HFpEF. Methods: A randomised crossover clinical trial is presented among people older than 70 years with a diagnosis of HFpEF. The experimental group will receive a cardiac rehabilitation intervention for 12 weeks. Participants in the control group will receive one educational session per week for 12 weeks on HFpEF complications, functional decline, and healthy lifestyle habits. VO2peak is the primary outcome. Biomechanical, imaging and physiological biomarkers will be assessed as secondary outcomes. Outcomes will be assessed at baseline, 12 weeks, and 24 weeks. Discussion: Identifying objective functional parameters indicative of HFpEF and the subsequent development of functional level stratification based on functional impairment ("biomechanical phenotypes") may help clinicians identify cardiac rehabilitation responders and non-responders and make future clinical decisions. In this way, future pharmacological and non-pharmacological interventions, such as exercise, could be improved and tailored to improve quality of life and prognosis and reducing patients' hospital readmissions, thereby reducing healthcare costs. Trial registration: NCT05393362 (Clinicaltrials.gov).es_ES
dc.description.abstractPatients with heart failure with preserved ejection fraction (HFpEF) have a low functional status, which in turn is a risk factor for hospital admission and an important predictor of survival in HFpEF. HFpFE is a heterogeneous syndrome and recent studies have suggested an important role for careful, pathophysiological-based phenotyping to improve patient characterization. Cardiac rehabilitation has proven to be a useful tool in the framework of secondary prevention in patients with HFpEF. Facilitating decision-making and implementing cardiac rehabilitation programs is a challenge in public health systems for HFpEF management. The FUNNEL + study proposes to evaluate the efficacy of an exercise and education-based cardiac rehabilitation program on biomechanical, physiological, and imaging biomarkers in patients with HFpEF.es_ES
dc.description.sponsorshipFunding for this work was provided by a competitive grant by the Spanish Government, Health Research Grant, Instituto de Salud Carlos III (ISCIII) Fondo de Investigacion Sanitaria (FIS; exp. (PI22/00315), cofunded by European Union, title “Efectividad de un programa de rehabilitación cardiaca en biomarcadores cinemáticos, estructurales y fisiológicos en pacientes de edad avanzada con insuficiencia cardíaca. FUNNEL +. The ISCIII is not involved in the study design, data collection, data analysis, data interpretation or report writing.es_ES
dc.identifier.citationCuesta-Vargas, A.I., Fuentes-Abolafio, I.J., García-Conejo, C. et al. Effectiveness of a cardiac rehabilitation program on biomechanical, imaging, and physiological biomarkers in elderly patients with heart failure with preserved ejection fraction (HFpEF): FUNNEL + study protocol. BMC Cardiovasc Disord 23, 550 (2023). https://doi.org/10.1186/s12872-023-03555-7es_ES
dc.identifier.doi10.1186/s12872-023-03555-7
dc.identifier.urihttps://hdl.handle.net/10630/32765
dc.language.isoenges_ES
dc.publisherSpringer Naturees_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.accessRightsopen accesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectSistema cardiovascular - Enfermedadeses_ES
dc.subject.otherCardiovascular rehabilitationes_ES
dc.subject.otherFrail elderly syndromees_ES
dc.subject.otherFunctional physical performancees_ES
dc.subject.otherHeart failurees_ES
dc.subject.otherPreserved ejection fraction; Sarcopeniaes_ES
dc.titleEffectiveness of a cardiac rehabilitation program on biomechanical, imaging, and physiological biomarkers in elderly patients with heart failure with preserved ejection fraction (HFpEF): FUNNEL + study protocoles_ES
dc.typejournal articlees_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication
relation.isAuthorOfPublication94126d4b-371d-4727-a252-f4182972d4b6
relation.isAuthorOfPublication6be2fc84-ad50-43e1-b5c7-ede79057e879
relation.isAuthorOfPublicationae123d5b-4c17-4d63-9708-e83f8477984a
relation.isAuthorOfPublication636ed082-6d1a-4c86-abe1-5a1dc630a6a7
relation.isAuthorOfPublicationaf904741-d538-4bf8-a882-d00782271171
relation.isAuthorOfPublication2f9b4b12-85ef-4742-8324-eafc98ed6805
relation.isAuthorOfPublication.latestForDiscovery94126d4b-371d-4727-a252-f4182972d4b6

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
s12872-023-03555-7.pdf
Size:
1.94 MB
Format:
Adobe Portable Document Format
Description:
Artículo principal
Download

Description: Artículo principal

Collections

Artículos