Bevacizumab plus low-dose metronomic oral cyclophosphamide in heavily pretreated patients with recurrent ovarian cancer
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Aim: To retrospectively assess the efficacy and safety of bevacizumab plus low-dose metronomic oral cyclophosphamide
in heavily pretreated patients with recurrent ovarian cancer. Patients and Methods: Patients with recurrent ovarian
cancer and prior treatment with platinum- and taxanebased chemotherapy were included. Treatment consisted of
bevacizumab 10 mg/kg intravenously every 2 weeks plus oral cyclophosphamide 50 mg daily until disease progression
or unacceptable toxicity. Response rates (RR) were determined according to RECIST criteria and by monitoring the
CA 125 serum tumor marker according to Rustin’s criteria.The endpoints were progression-free survival (PFS), RR, overall
survival (OS), and safety. Results: Thirty-eight patients were treated; 79% were platinum resistant and 21% were
platinum sensitive. The median number of previous treatments was 4 (range 1–8). Seventy-nine percent of patients
had received more than 2 previous lines of treatment. Eightyone percent of patients had received gemcitabine, 76% liposomal
doxorubicin, and 50% topotecan. A median of 8 (range 1–70) cycles of bevacizumab were administered. The overall
RR was a complete response (CR) in 3 patients (8.1%), a partial response (PR) in 12 (32.4%), and stable disease (SD) 6 6
months in 3 (8.1%). The median PFS and OS were 4.5 and 10.7 months, respectively. Thirty-nine percent of patients were
progression free for at least 6 months. In an exploratory analysis there was a significant relation of prior platinum response
and performance status with the risk of progression.Grade 3–4 toxicities included anemia (1), hypertension (2),
hematuria (1), arterial thrombosis in the leg (1), dyspnea (1), and intestinal fistulae (1). There were no cases of gastrointestinal
perforation (GIP) or treatment-related deaths. Conclusion: The combination of bevacizumab and metronomic cyclophosphamide
was active and well-tolerated in heavily pretreated patients with recurrent ovarian cancer.
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Este artículo ha sido publicado en Oncology Basel.
Esta versión tiene Licencia Creative Commons CC-BY-NC-ND
No puedo enviar el postprint porque no lo tienen disponible o no quieren facilitarmelo, en su lugar he aportado en la descripción del envió dos e mail en los cuales la editorial me da permiso por escrito para su depósito como puede ver en los mimos
Adjunto e mails, si tiene ustd alguna otra sugerencia para poder hacer deposito por favor hagamelo saber
2º e mail:
Dear Alfonso,
Our reply is the written permission to deposit the article in the university’s repository – please find it attached once again.
Kind regards,
Veronika
1º e mail
Veronika Duhovnikova
Key Account Manager, Academic & Research Markets
+41 61 306 12 43
v.duhovnikova@karger.com
Dear Alfonso,
Thank you for your email. As to your query, we are pleased to inform you that Karger permits authors to archive their pre-prints (i.e. pre-peer review) or post-prints (i.e. accepted manuscript after peer review but before production) on their personal or their institution’s internal website. In addition, authors may post their accepted manuscripts in public Open Access repositories and scientific networks (e.g. ResearchGate or Mendeley) no earlier than 12 months following the publication of the publisher’s versions.
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For papers published online first with a DOI number only, full citation details must be added as soon as the paper is published in its final version. This is important to ensure that citations can be credited to the article.
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Kind regards,
Veronika
Veronika Duhovnikova
Key Account Manager, Academic & Research Markets
+41 61 306 12 43
v.duhovnikova@karger.com
Bibliographic citation
Sánchez-Muñoz A, Mendiola C, Pérez-Ruiz E, Rodríguez-Sánchez CA, Jurado JM, Alonso-Carrión L, Ghanem I, de Velasco G, Quero-Blanco C, Alba E. Bevacizumab plus low-dose metronomic oral cyclophosphamide in heavily pretreated patients with recurrent ovarian cancer. Oncology. 2010;79(1-2):98-104. doi: 10.1159/000320602. Epub 2010 Nov 15. PMID: 21079407.
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