Association between variation of circulating 25-OH vitamin D and methylation of secreted frizzled-related protein 2 in colorectal cancer

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dc.contributor.authorBoughanem Lakhal, Hatim
dc.contributor.authorCabrera-Mulero, Amanda
dc.contributor.authorHernández Alonso, Daniel
dc.contributor.authorClemente-Postigo, María Mercedes
dc.contributor.authorCasanueva, Felipe F.
dc.contributor.authorTinahones-Madueño, Francisco José
dc.contributor.authorMorcillo Espina, Sonsoles
dc.contributor.authorCrujeiras Martínez, Ana Belén
dc.contributor.authorMacías-González, Manuel
dc.date.accessioned2024-12-17T09:07:20Z
dc.date.available2024-12-17T09:07:20Z
dc.date.issued2020
dc.departamentoBiología Celular, Genética y Fisiología
dc.description.abstractColorectal cancer (CRC) results from the accumulation of epigenetic and genetic changes in colon cells during neoplasic transformation, which the activation of Wingless (Wnt) signaling pathway is a common mechanism for CRC initiation. The Wnt pathway is mainly regulated by Wnt antagonists, as secreted frizzled-related protein (SFRP) family. Indeed, SFRP2 is proposed as a noninvasive biomarker for CRC diagnosis. Vitamin D also antagonizes Wnt signaling in colon cancers cells. Several studies showed that vitamin D was able to alter DNA methylation, although this mechanism is not yet clear. Therefore, the aim of this study was to find an association between circulating 25-OH vitamin D (30th percentile of vitamin D) and the SFRP2 methylation.es_ES
dc.identifier.citationBoughanem, H., Cabrera-Mulero, A., Hernández-Alonso, P. et al. Association between variation of circulating 25-OH vitamin D and methylation of secreted frizzled-related protein 2 in colorectal cancer. Clin Epigenet 12, 83 (2020). https://doi.org/10.1186/s13148-020-00875-9es_ES
dc.identifier.doi10.1186/s13148-020-00875-9
dc.identifier.urihttps://hdl.handle.net/10630/35698
dc.language.isoenges_ES
dc.publisherSpringer Naturees_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.accessRightsopen accesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectColon - Cánceres_ES
dc.subjectRecto - Cánceres_ES
dc.subject.otherSFRP2 methylationes_ES
dc.subject.other25-OH vitamin Des_ES
dc.subject.otherColorectal canceres_ES
dc.subject.otherNeoadjuvant treatmentes_ES
dc.titleAssociation between variation of circulating 25-OH vitamin D and methylation of secreted frizzled-related protein 2 in colorectal canceres_ES
dc.typejournal articlees_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication
relation.isAuthorOfPublication46c3f5cc-8da4-4e02-a354-41cd13a773ce
relation.isAuthorOfPublication5008638f-787f-4d12-81ea-8f34216949a5
relation.isAuthorOfPublication.latestForDiscovery46c3f5cc-8da4-4e02-a354-41cd13a773ce

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