Interferon receptor expression in multiple sclerosis patients

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dc.contributor.authorOliver-Martos, Begoña
dc.contributor.authorMayorga Mayorga, Cristobalina
dc.contributor.authorLeyva-Fernández, Laura
dc.contributor.authorLeón, Antonio
dc.contributor.authorLuque, Gloria
dc.contributor.authorC Lopez, Juan
dc.contributor.authorTamayo, Jose A
dc.contributor.authorPinto-Medel, Maria Jesús
dc.contributor.authorDe Ramón, Enrique
dc.contributor.authorBlanco, Eva
dc.contributor.authorAlonso, Ana
dc.contributor.authorFernández Fernández, Óscar
dc.date.accessioned2024-09-30T08:58:01Z
dc.date.available2024-09-30T08:58:01Z
dc.date.issued2006
dc.departamentoBiología Celular, Genética y Fisiología
dc.description.abstractTo determine the gene expression of IFNAR1, IFNAR2 and MxA protein and the association with IFNbeta treatment response in MS patients. MS patients treated with IFNbeta had a significant decrease in IFNAR1 and IFNAR2 expression, and a significant increase in MxA compared to non-treated patients and healthy controls. Also, those patients who had a good response to treatment had a significant decrease in IFNAR1 and IFNAR2 expression compared to non-responders, non-treated patients and healthy controls. IFNbeta influences the expression of its receptors, and is greater in patients who respond to IFNbeta treatment. This down-regulation could be indicative of the response to IFNbeta.es_ES
dc.identifier.citationOliver B, Mayorga C, Fernández V, Leyva L, León A, Luque G, López JC, Tamayo JA, Pinto-Medel MJ, de Ramon E, Blanco E, Alonso A, Fernández O. Interferon receptor expression in multiple sclerosis patients. J Neuroimmunol. 2007 Feb;183(1-2):225-31. doi: 10.1016/j.jneuroim.2006.11.010. Epub 2006 Dec 26. PMID: 17188754.es_ES
dc.identifier.doi0.1016/j.jneuroim.2006.11.010
dc.identifier.urihttps://hdl.handle.net/10630/33967
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rights.accessRightsopen accesses_ES
dc.subjectEsclerosis múltiplees_ES
dc.subject.otherIFNARes_ES
dc.subject.otherMxAes_ES
dc.subject.otherInterferon betaes_ES
dc.subject.otherMultiple sclerosises_ES
dc.titleInterferon receptor expression in multiple sclerosis patientses_ES
dc.typejournal articlees_ES
dc.type.hasVersionAMes_ES
dspace.entity.typePublication
relation.isAuthorOfPublication914cfcd0-cf48-43b1-a75b-2f8c53238c29
relation.isAuthorOfPublication90dc288c-2403-4516-b966-5b83e114abcd
relation.isAuthorOfPublication.latestForDiscovery914cfcd0-cf48-43b1-a75b-2f8c53238c29

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