A lower duodenal immune response is associated with an increase of insulin resistance in patients with morbid obesity

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dc.centroFacultad de Medicinaes_ES
dc.contributor.authorHo-Plágaro, Ailec
dc.contributor.authorSaltiago-Fernández, Concepción
dc.contributor.authorGarcía Serrano, Sara
dc.contributor.authorRodríguez, Cristina
dc.contributor.authorGarrido-Sánchez, Lourdes
dc.contributor.authorEscamilla-Sánchez, Alejandro
dc.contributor.authorGonzalo, Montserrat
dc.contributor.authorMontiel Casado, Custodia
dc.contributor.authorAlcaín-Martínez, Guillermo
dc.contributor.authorGarcía-Muñoz, Beatriz
dc.contributor.authorRuiz-Santana, Natalia
dc.contributor.authorVázquez Pedreño, Luis
dc.contributor.authorGarcía-Fuentes, Eduardo
dc.date.accessioned2025-01-13T08:25:29Z
dc.date.available2025-01-13T08:25:29Z
dc.date.created2024-12-23
dc.date.issued2019-09-25
dc.departamentoFisiología Humana, Histología Humana, Anatomía Patológica y Educación Físico Deportiva
dc.description.abstractThe intestinal immune response could play an important role in obesity-related comorbidities. We aim to study the profile of duodenal cytokines and chemokines in patients with morbid obesity (MO), its relation with insulin resistance (IR) and the intake of metformin, and with the evolution of MO after sleeve gastrectomy (SG). In our work there is an association between a higher IR and a lower duodenal immune response in MO, with a slight increase in those patients with metformin treatment. Intestinal immune response could be involved in the evolution of BMI after SG.es_ES
dc.description.sponsorshipCIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN) and CIBER de Diabetes y Enfermedades Metabólicas (CIBERDEM) are initiatives of ISCIII (Spain). We gratefully acknowledge the Imaging platform of the Institute of Biomedical Research in Malaga (IBIMA) (Spain). This work was supported in part by a grant from the Instituto de Salud Carlos III, Spain (PI12/00338) (“Una manera de hacer Europa”). This study has been co-funded by FEDER funds. AHP is supported by a grant from the Ministerio de Educación y Formación Professional (Spain) (FPU14/01972). CSF is supported by a grant from the ISCIII (Spain) (FI16/00241). LGS is supported by the Miguel Servet program from the ISCIII (Spain) (MS13/00188). CR is supported by a grant from BEIPD-COFUNDOPD, (Belgium) (R.EURO.0992-J-F-B-32). EGF is supported by the Nicolas Monardes program from the Consejería de Salud de Andalucía (Spain) (C-0031-2016).es_ES
dc.identifier.citationHo-Plagaro, A., Santiago-Fernandez, C., García-Serrano, S., Rodriguez, C., Garrido-Sanchez, L., Escamilla, A., Gonzalo, M., Montiel-Casado, C., Alcaín-Martínez, G., Garcia-Muñoz, B., Ruiz-Santana, N., Vázquez-Pedreño, L., & Garcia-Fuentes, E. (2020). A lower duodenal immune response is associated with an increase of insulin resistance in patients with morbid obesity. International journal of obesity (2005), 44(2), 340–352. https://doi.org/10.1038/s41366-019-0458-1es_ES
dc.identifier.doi10.1038/s41366-019-0458-1
dc.identifier.urihttps://hdl.handle.net/10630/36157
dc.language.isoenges_ES
dc.publisherSpringer Naturees_ES
dc.rights.accessRightsopen accesses_ES
dc.subjectHistologíaes_ES
dc.subjectObesidades_ES
dc.subject.otherHistologyes_ES
dc.subject.otherObesityes_ES
dc.subject.otherEndocrinologyes_ES
dc.subject.otherImmunopathologyes_ES
dc.titleA lower duodenal immune response is associated with an increase of insulin resistance in patients with morbid obesityes_ES
dc.typejournal articlees_ES
dc.type.hasVersionSMURes_ES
dspace.entity.typePublication
relation.isAuthorOfPublicationc3d26d14-edbf-4629-a055-e5bad81c9f99
relation.isAuthorOfPublication.latestForDiscoveryc3d26d14-edbf-4629-a055-e5bad81c9f99

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