Tumor immune escape by autotaxin: keeping eosinophils at bay
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Description: Articulo publicado en revista Trends in cancer en abril de 2024. Volume 10, Issue 4 , April 2024, Pages 283-285
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Matas-Rico, Elisa
Moolenaar, Wouter H
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Elsevier
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Abstract
Secreted autotaxin (ATX) promotes tumor progression by producing the pleiotropic lipid
mediator lysophosphatidic acid
(LPA). In a recent Nature Cancer
paper, Bhattacharyya et al. show
that ATX/LPA signaling suppresses
CCL11-driven infiltration of eosinophils into the pancreatic tumor
microenvironment to facilitate
tumor progression, thus revealing
a new ATX-mediated immune
escape mechanism and highlighting the antitumor potential of
eosinophils
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Elisa Matas-Rico, Wouter H. Moolenaar, Tumor immune escape by autotaxin: keeping eosinophils at bay, Trends in Cancer, Volume 10, Issue 4, 2024, Pages 283-285, ISSN 2405-8033, https://doi.org/10.1016/j.trecan.2024.03.002. (https://www.sciencedirect.com/science/article/pii/S2405803324000517)