One hundred of cells generations connect the resistance to drugs and the replicative aging mechanisms
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Abstract
There are researchs that reveal a relationship between acquired resistance to antineoplastic drugs and aging.
Therefore, the identification of genes involved in senescence could have a potential therapeutic utility for the prediction and/or prevention of resistance to antineoplastic drugs.
The aim of this work is to study the relationship between replicative aging and acquired resistance to Cisplatin and Bleomycin in the yeast Saccharomyces cerevisiae.
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