High Prevalence of Ibuprofen Drug-Induced Liver Injury in Spanish and Latin-American Registries.

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dc.centroFacultad de Medicinaes_ES
dc.contributor.authorZoubek, Miguel E.
dc.contributor.authorGonzález-Jiménez, Andrés
dc.contributor.authorMedina-Cáliz, Inmaculada
dc.contributor.authorRobles-Díaz, María Mercedes
dc.contributor.authorHernandez, Nelia
dc.contributor.authorRomero-Gomez, Manuel
dc.contributor.authorBessone, Fernando
dc.contributor.authorHallal, Hacibe
dc.contributor.authorCubero, Francisco Javier
dc.contributor.authorLucena-González, María Isabel
dc.contributor.authorStephens, Camilla
dc.contributor.authorAndrade-Bellido, Raúl Jesús
dc.date.accessioned2025-10-17T07:27:47Z
dc.date.available2025-10-17T07:27:47Z
dc.date.issued2018-02
dc.departamentoFarmacología y Pediatríaes_ES
dc.descriptionhttps://openpolicyfinder.jisc.ac.uk/id/publication/4740es_ES
dc.description.abstractNonsteroidal anti-inflammatory drugs (NSAIDs) are responsible for 3% to 10% of idiosyncratic drug-induced liver injury (DILI) cases in the Western world.1–3 Ibuprofen is a widely prescribed NSAID avail- able as over-the-counter medication (OTC), and perceived as having a better safety profile than many other NSAIDs. Interestingly, striking regional differences in the frequency of ibuprofen hepatotoxicity were noted in a comparison of causative DILI agents among large DILI cohorts in 2010.4 Based on the limited information available on this type of DILI, we aimed to analyze the clinical presentation of ibuprofen-associated hepatotox- icity in the search for a potential drug signature.es_ES
dc.identifier.citationZoubek ME, González-Jimenez A, Medina-Cáliz I, Mercedes Robles-Díaz, Hernandez N, Romero-Gómez R, Bessone F, Hallal H, Cubero FJ, Lucena MI, Stephens C, Andrade RJ. High Prevalence of Ibuprofen Drug-Induced Liver Injury in Spanish and Latin-American Registries. Clin Gastroenterol Hepatol 2018 Feb;16(2):292-294es_ES
dc.identifier.doi10.1016/j.cgh.2017.07.037
dc.identifier.urihttps://hdl.handle.net/10630/40286
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.accessRightsopen accesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectHepatotoxicidades_ES
dc.subjectHígado - Lesiones y heridases_ES
dc.subjectIbuprofeno - Efectos secundarioses_ES
dc.subject.otherhepatotoxicityes_ES
dc.subject.otherNSAIDes_ES
dc.subject.otheradverse reactiones_ES
dc.titleHigh Prevalence of Ibuprofen Drug-Induced Liver Injury in Spanish and Latin-American Registries.es_ES
dc.typejournal articlees_ES
dc.type.hasVersionAMes_ES
dspace.entity.typePublication
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relation.isAuthorOfPublication4bb1f619-da0e-40a4-a809-0687a455f6be
relation.isAuthorOfPublication129ea2d9-e856-47ce-aa53-4f4af697017b
relation.isAuthorOfPublicationa6176e8b-aafd-4214-af5c-8343612c72ca
relation.isAuthorOfPublication.latestForDiscoveryc049772e-c383-4e34-99ab-db30fe7ddfa3

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