Non-targeted metabolomics characterization of Annona muricata leaf extracts with anti-angiogenic activity

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dc.centroFacultad de Cienciases_ES
dc.contributor.authorCárdenas García, Casimiro
dc.contributor.authorTorres-Vargas, José Antonio
dc.contributor.authorCárdenas Valdivia, Abel
dc.contributor.authorJurado, Nuria
dc.contributor.authorRodríguez-Quesada, Ana María
dc.contributor.authorGarcía-Caballero, Melissa
dc.contributor.authorMartínez-Póveda, Beatriz Amparo
dc.contributor.authorMedina-Torres, Miguel Ángel
dc.date.accessioned2022-04-26T09:23:48Z
dc.date.available2022-04-26T09:23:48Z
dc.date.issued2021-11
dc.departamentoBiología Molecular y Bioquímica
dc.description.abstractThe tropical plant Annona muricata has been widely used for traditional ethnobotanic and pharmacologic applications. Extracts from different parts of this plant have been shown to have a wide range of biological activities. In the present study, we carry out a metabolomic study of both aqueous and DMSO extracts from Annona muricata leaves that has allowed us to identify 33 bioactive compounds. Furthermore, we have shown that aqueous extracts are able to inhibit endothelial cell migration and both aqueous and DMSO extracts inhibit the formation of tubule-like structures by endothelial cells cultured on Matrigel. We conclude that extracts of Annona muricata leaves have great potential as anti-angiogenic natural combinations of bioactive compounds.es_ES
dc.description.sponsorshipFunding for open access charge: Universidad de Málaga / CBUA. This work was supported by grants PID2019-105010RB-I00 (Spanish Ministry of Science, Innovation and Universities), UMA18-FEDERJA220, UMA18-FEDERJA-267 and PY20_00257 (Andalusian Government and FEDER) and funds from group BIO 267 (Andalusian Government). The “CIBER de Enfermedades Raras” and “CIBER de Enfermedades Vasculares” are initiatives from the ISCIII (Spain). The funders had no role in the study design, data collection and analysis, decision to publish or preparation of the manuscript.
dc.identifier.citationCárdenas, Casemiro ; Torres-Vargas, José Antonio ; Cárdenas Valdivia, Abel ; Jurado, Nuria ; Rodriguez-Quesada, Ana Maria ; García-Caballero, Melissa ; Martínez Poveda, Beatriz ; Medina Torres, Miguel Ángel. Non-targeted metabolomics characterization of Annona muricata leaf extracts with anti-angiogenic activity. Biomedicine & Pharmacotherapy Volume 144, December 2021, 112263. https://doi.org/10.1016/j.biopha.2021.112263es_ES
dc.identifier.doi10.1016/j.biopha.2021.112263
dc.identifier.urihttps://hdl.handle.net/10630/23975
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.accessRightsopen accesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectNeovascularizaciónes_ES
dc.subject.otherUltra-high-performance liquid chromatography-high-resolution mass spectrometry (UHPLC–HRMS)es_ES
dc.subject.otherAnnona muricataes_ES
dc.subject.otherGraviolaes_ES
dc.subject.otherSoursopes_ES
dc.subject.otherAngiogenesises_ES
dc.titleNon-targeted metabolomics characterization of Annona muricata leaf extracts with anti-angiogenic activityes_ES
dc.typejournal articlees_ES
dc.type.hasVersionVoR
dspace.entity.typePublication
relation.isAuthorOfPublication64ecf6af-9938-4725-9539-659cb04fae88
relation.isAuthorOfPublication796ec342-e395-494c-a22d-ce9adbad34d5
relation.isAuthorOfPublicationdddb6cd7-0e48-4c9d-82c7-d80fe8b23544
relation.isAuthorOfPublication.latestForDiscovery64ecf6af-9938-4725-9539-659cb04fae88

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