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Dopamine D2 and D4 receptor heteromerization and its allosteric receptor-receptor interactions

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dc.centroFacultad de Medicina
dc.contributor.authorBorroto-Escuela, Dasiel O.
dc.contributor.authorCraenenbroeck, Kathleen Van
dc.contributor.authorRomero-Fernandez, Wilber
dc.contributor.authorGuidolin, Diego
dc.contributor.authorWoods, Amina S.
dc.contributor.authorRivera, Alicia
dc.contributor.authorHaegeman, Guy
dc.contributor.authorAgnati, Luigi F.
dc.contributor.authorTarakanov, Alexander O.
dc.contributor.authorFuxe, Kjell
dc.date.accessioned2026-01-29T11:44:56Z
dc.date.issued2011-01-28
dc.departamentoFisiología Humana, Histología Humana, Anatomía Patológica y Educación Físico Deportiva
dc.description.abstractDopamine D2 and D4 receptors partially codistribute in the dorsal striatum and appear to play a fundamental role in complex behaviors and motor function. The discovery of D2R-D4.xR (D4.2R, D4.4R or D4.7R) heteromers has been made in cellular models using co-immunoprecipitation, in situ Proximity Ligation Assays and BRET1 techniques with the D2R and D4.7R receptors being the least effective in forming heteromers. Allosteric receptor-receptor interactions in D2R-D4.2R and D2R-D4.4 R heteromers were observed using the MAPK assays indicating the existence of an enhancing allosteric receptor-receptor interaction in the corresponding heteromers between the two orthosteric binding sites. The bioinformatic predictions suggest the existence of a basic set of common triplets (ALQ and LRA) in the two participating receptors that may contribute to the receptor-receptor interaction interfaces.
dc.description.sponsorshipSwedish Research Council (Vetenskapsrådet)
dc.description.sponsorshipTorsten and Ragnar Söderberg
dc.description.sponsorshipM.M. Wallenberg Foundation
dc.identifier.citationDasiel O. Borroto-Escuela, Kathleen Van Craenenbroeck, Wilber Romero-Fernandez, Diego Guidolin, Amina S. Woods, Alicia Rivera, Guy Haegeman, Luigi F. Agnati, Alexander O. Tarakanov, Kjell Fuxe, Dopamine D2 and D4 receptor heteromerization and its allosteric receptor–receptor interactions, Biochemical and Biophysical Research Communications, Volume 404, Issue 4, 2011, Pages 928-934, ISSN 0006-291X, https://doi.org/10.1016/j.bbrc.2010.12.083.
dc.identifier.doi10.1016/j.bbrc.2010.12.083
dc.identifier.issn1090-2104
dc.identifier.urihttps://hdl.handle.net/10630/45029
dc.language.isoeng
dc.publisherElsevier
dc.relation.projectIDinfo:eu-repo/grantAgreement/Swedish_Research_Council//62X-00715-50-3/SE///
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectReceptores
dc.subjectDopamina - Receptores
dc.subject.otherDopamine D2R receptor
dc.subject.otherDopamine D4R receptor
dc.subject.otherG protein-coupled receptors
dc.subject.otherAllosteric modulation
dc.subject.otherHeteroreceptor complexes
dc.subject.otherReceptor-receptor interactions
dc.subject.otherHeteromerization
dc.titleDopamine D2 and D4 receptor heteromerization and its allosteric receptor-receptor interactions
dc.typejournal article
dc.type.hasVersionAM
dspace.entity.typePublication

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