Effects of glucagon-like peptide-1 on the differentiation and metabolism of human adipocytes.

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dc.contributor.authorEl-Bekay, Rajaa
dc.contributor.authorCoín-Aragüez, Leticia I.
dc.contributor.authorFernandez-García, Diego
dc.contributor.authorOliva Olivera, Wilfredo
dc.contributor.authorBernal-López, María Rosa
dc.contributor.authorClemente-Postigo, María Mercedes
dc.contributor.authorDelgado-Lista, Javier
dc.contributor.authorDíaz-Ruiz, Alberto
dc.contributor.authorGuzmán-Ruiz, Rocio
dc.contributor.authorVázquez-Martínez, Rafael
dc.contributor.authorLhamyani, Said
dc.contributor.authorRoca-Rodríguez, María del Mar
dc.contributor.authorFernández-Veledo, Sonia
dc.contributor.authorVendrell, Joan
dc.contributor.authorMalagón, Maria M.
dc.contributor.authorTinahones-Madueño, Francisco José
dc.date.accessioned2024-10-14T09:29:23Z
dc.date.available2024-10-14T09:29:23Z
dc.date.issued2016-03-18
dc.departamentoBiología Celular, Genética y Fisiología
dc.descriptionhttps://v2.sherpa.ac.uk/id/publication/6832es_ES
dc.description.abstractGlucagon-like peptide-1 (GLP-1) analogues improve glycaemic control in type 2 diabetic (T2D) patients and cause weight loss in obese subjects by as yet unknown mechanisms. We recently demonstrated that the GLP-1 receptor, which is present in adipocytes and the stromal vascular fraction of human adipose tissue (AT), is up-regulated in AT of insulin-resistant morbidly obese subjects compared with healthy lean subjects. The aim of this study was to explore the effects of in vitro and in vivo administration of GLP-1 and its analogues on AT and adipocyte functions from T2D morbidly obese subjects.es_ES
dc.description.sponsorshipThis work was supported by grants from the Spanish Ministry of Health (FIS) (PI12/02355, PS09/00997 and PI13/02628), the Consejería de Innovación and co-funded by Fondo Europeo de Desarrollo Regional–FEDER (CTS04369, CTS-03039, PI11-CTS-8181 and PI11-CTS-7895) and the Ministerio de Economía y Competitividad and co-funded by Fondo Europeo de Desarrollo Regional–FEDER (BFU2010–17116). Rajaa El Bekay is recipient of a post-doctoral grant ‘Miguel Servet II’ (CPII13/00041) from the Spanish Ministry of Health. CIBERobn is an initiative of ISCIII (Instituto de Salud Carlos III), Spain. M.C.P. was recipient of a FPU grant from the Ministry of Education (Spain) (AP2009–4537).es_ES
dc.identifier.doi10.1111/bph.13481
dc.identifier.urihttps://hdl.handle.net/10630/34724
dc.language.isoenges_ES
dc.publisherBritish Pharmacological Societyes_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.accessRightsopen accesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectPéptidoses_ES
dc.subjectObesidad - Aspectos moleculareses_ES
dc.subjectTejido adiposoes_ES
dc.subject.otherObesityes_ES
dc.subject.otherAdipocytees_ES
dc.subject.otherGlucagon-Like Peptide 1 (GLP1)es_ES
dc.titleEffects of glucagon-like peptide-1 on the differentiation and metabolism of human adipocytes.es_ES
dc.typejournal articlees_ES
dc.type.hasVersionAMes_ES
dspace.entity.typePublication
relation.isAuthorOfPublication46c3f5cc-8da4-4e02-a354-41cd13a773ce
relation.isAuthorOfPublication5008638f-787f-4d12-81ea-8f34216949a5
relation.isAuthorOfPublication.latestForDiscovery46c3f5cc-8da4-4e02-a354-41cd13a773ce

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