An early-exercise-mediated adverse reaction associated with platelet-rich plasma therapy: A Case Report

Abstract

Purpose: Platelet Rich Plasma (PRP) is a well-established autologous therapy with several indications in the musculoskeletal spectrum with a few reported complications. PRP pathophysiologic mechanism remains unclear so cause-effect relationships are difficult to be established. To our knowledge, acute inflammatory reactions associated with intra-articular PRP injection have never been reported. We herein present a rare case of adverse reaction in a patient who exercised after only 16 hours from PRP therapy. Methods: She was admitted to hospital with sensation of fever, pain and inflammation of the knee 8 hours after the training session and 24 hours after last PRP injection. Results: Laboratory studies did not reveal any infection sign. Once the clinical picture was resolved, the patient was able to resume previous activity level. Conclusion: In this case, early exercise-related adverse reaction following PRP therapy may have played a role via mediating stimulus as a causative factor.