SYT6: a newly identified protein involved in ER - trans-Golgi network Membrane Contact Sites

Abstract

SYT6 is a newly identified lipid transport protein from ER - trans-Golgi network Membrane Contact Sites. Our results show that: • SYT6 contacts trans-Golgi network vesicles through its coiled-coil domain. • SYT6 can efectively respond to Ca2+ using its terminal C2C domain. • SYT6-C2 domains preferentially bind to negatively charged membranes (with PI4P and PS) in presence of Ca2+.