Glutaminase isoenzymes in the metabolic 1 therapy of cancer

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dc.centroFacultad de Cienciases_ES
dc.contributor.authorMates-Sánchez, José Manuel
dc.contributor.authorCampos-Sandoval, José Ángel
dc.contributor.authorMárquez-Gómez, Javier
dc.date.accessioned2025-01-30T11:59:49Z
dc.date.available2025-01-30T11:59:49Z
dc.date.created2025-01-27
dc.date.issued2018-07
dc.departamentoBiología Molecular y Bioquímica
dc.descriptionMensaje de la editorial Elsevier: Dear Dr. José A. Campos-Sandoval, I have attached the accepted version of your manuscript for your reference. Kindly check and let me know if you need any further assistance. Best regards, Narmatha Journal Manageres_ES
dc.description.abstractAltered cellular metabolism is a hallmark of cancer. Cancer cells express isoforms of metabolic enzymes that may constitute therapeutic targets. Glutaminase controls glutamine metabolism and their expression correlate with malignancy of tumours. The two types of glutaminase isoenzymes, GLS and GLS2, differ in their expression patterns and functional roles: GLS has oncogenic properties and GLS2 has been described as a tumour suppressor factor. Selective genomic and epigenomic intervention over glutaminase affects the metabolic reprogramming of cancer. This review highlights the molecular metabolic vulnerabilities in various types of cancer, to be used for biomarker development, drug design, and in personalized oncology.es_ES
dc.identifier.citationJosé M. Matés, José A. Campos-Sandoval, Javier Márquez, Glutaminase isoenzymes in the metabolic therapy of cancer, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1870, Issue 2, 2018, Pages 158-164, ISSN 0304-419X, https://doi.org/10.1016/j.bbcan.2018.07.007. (https://www.sciencedirect.com/science/article/pii/S0304419X1830101X)es_ES
dc.identifier.doi10.1016/j.bbcan.2018.07.007
dc.identifier.urihttps://hdl.handle.net/10630/37401
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rights.accessRightsopen accesses_ES
dc.subjectCáncer - Aspectos moleculareses_ES
dc.subjectAntiangiogénicoses_ES
dc.subject.otherCancer metabolismes_ES
dc.subject.otherCombinatory therapyes_ES
dc.subject.otherGlutaminase inhibitorses_ES
dc.subject.otherGlutaminees_ES
dc.subject.otherGlutaminase isoenzymeses_ES
dc.subject.otherMetabolic reprogramminges_ES
dc.titleGlutaminase isoenzymes in the metabolic 1 therapy of canceres_ES
dc.typejournal articlees_ES
dc.type.hasVersionAMes_ES
dspace.entity.typePublication
relation.isAuthorOfPublication299e4d58-4577-483c-9cef-6a4fe31e633d
relation.isAuthorOfPublication46fdb5a5-833c-41b3-bdb6-85e10b00fc2d
relation.isAuthorOfPublication1bfd5e40-c8ac-4290-93e6-462f50f4e8d0
relation.isAuthorOfPublication.latestForDiscovery299e4d58-4577-483c-9cef-6a4fe31e633d

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