Selection of resistance to cisplatin in saccharomyces cerevisiae as a model for antineoplastic drugs studies
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The budding yeast (S. cerevisiae) is an excellent eukaryotic model to study the antineoplastic drugs effects, due to the well-characterized metabolic and genetic characteristics and the conserved similarity in molecular mechanisms with other species including human cells.
The aim of this work is to study the effect of cisplatin on S. cerevisiae cells and select cisplatin-resistant cells of this organism as a model of study of resistance to antineoplastic drugs.
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