RT Conference Proceedings
T1 Gastrointestinal cancer: Relationship between histology and microbiota
A1 García Sanz, A
A1 Escamilla-Sánchez, Alejandro
A1 Mercado-Sáenz, Silvia
A1 Rodríguez-Pérez, Luis Manuel
A1 Arranz-Salas, Isabel María
A1 Sánchez-Varo, Raquel María
A1 Peláez-González, Alberto Carlos
A1 López-Villodres, Juan Antonio
A1 Bermúdez-Flores, Diego Teófilo
K1 Intestino - Cáncer
K1 Estómago - Cáncer
AB Objectives: Review of the published literature concerning the relationship between microbiome and gastrointestinal cancer.Methods: Present work is focused on systematic research in the most prominent biomedical databases finds relevant works in Pubmed and the library’s catalog of the University of Málaga (Jábega) of published journals in the last 5 years.Results: In this work, the mechanisms used by the microbiome to damage gastrointestinal epithelial cells and cause cancer are explained. Some of them are the dysbiosis, destruction of the mucosal barrier, chronic inflammation, damage caused by metabolites produced in the digestion and the direct attack of certain toxins to the cell’s DNA. These mechanisms adjust the immune response, by activation or inhibition using different cytokines. There is also a deeper look into several microorganisms and how they cause gastrointestinal cancer using toxins or virulence factors to activate them.Conclusions: The evidence found so far about the microbiota and gastrointestinal cancer is enough to assume the relationship between them, although there is much left to research. With these findings, it can be expected that in a near future certain microorganisms could be used for screening purposes, due to their increase in early stages of the tumor genesis and also, in a preventive way to try to eradicate them, even avoid cancer. Studies on the microbiota are hardly beginning, and results appear to be promising.
YR 2022
FD 2022-09-09
LK https://hdl.handle.net/10630/25032
UL https://hdl.handle.net/10630/25032
LA spa
NO Este trabajo fue presentado como comunicación tipo póster en el citado congreso.
NO Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026