RT Journal Article
T1 Serum protein levels following surgery in breast cancer patients: A protein microarray approach
A1 Pérez-Rivas, Luis G.
A1 Jérez, J.M.
A1 Fernández-De Sousa, C.E.
A1 De Luque, Vanessa
A1 Quero, C.
A1 Pajares, Bella
A1 Franco, L.
A1 Sánchez-Muñoz, Alfonso
A1 Ribelles, Nuria
A1 Alba-Conejo, Emilio
K1 Mamas - Cáncer - Investigación
AB Surgery is the primary treatment for non-metastaticbreast cancer. However, the risk of early recurrence remainsafter surgical removal of the primary tumor. Recurrence issuggested to result from hidden micrometastatic foci, whichare triggered to escape from dormancy by surgical resection ofthe primary tumor. In this study, we focused on the differentialimpact of breast surgery on the serum profiles of early breastcancer patients and healthy women. Serum samples frominvasive breast cancer patients, in situ carcinoma breast cancerpatients and healthy women were analyzed using reverse phaseprotein array technology. Samples were collected prior to breastsurgery and 24 h following breast surgery. Both the expressionlevel and the velocity of 42 serum proteins were quantified andcompared among groups. We found that surgery increasedthe concentration of several proteins (CSF1, THSB2, IL6, IL7,IL16, FasL and VEGF-B) in the overall population. Comparedwith healthy women and patients with non-invasive tumors,invasive tumor patients exhibited higher preoperative levels ofseveral serum proteins, such as αFP, IFNβ1, VEGF-A, IL18,E-cadherin or CD31, and lower postoperative levels of TNFαand IL5. Similarly, we detected significant surgery-inducedchanges in the velocity of VEGF-A and IL16 accumulationin samples derived from invasive breast cancer patients. Inconclusion, breast surgery induced distinct changes in theconcentrations and dynamics of serum proteins in invasivebreast cancer patients compared with healthy women and noninvasivetumor patients.
PB Spandidos Publications
YR 2012
FD 2012-07
LK https://hdl.handle.net/10630/29754
UL https://hdl.handle.net/10630/29754
LA eng
NO Perez-Rivas LG, Jerez JM, Fernandez-De Sousa CE, de Luque V, Quero C, Pajares B, Franco L, Sanchez-Muñoz A, Ribelles N, Alba E. Serum protein levels following surgery in breast cancer patients: a protein microarray approach. Int J Oncol. 2012 Dec;41(6):2200-6. doi: 10.3892/ijo.2012.1667. Epub 2012 Oct 16. PMID: 23076779.
NO Este artículo ha sido publicado en INTERNATIONAL JOURNAL OF ONCOLOGYNo hemos podido encontrar infomración sobre si permite depositar conlicencia creative CommonsEl archivo solicitado a la editorial como postprint que nos ha remitido es el que depositamos
NO The authors acknowledge support through grants from the Junta de Andalucia (0199/2006 and TIC-4026), the FundacionMutua Madrileña and the Spanish MINECO (TIN2010-16556).
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 21 ene 2026