RT Journal Article
T1 Unwanted or Negative Treatment Reactions in Digital Psychological Interventions for Adolescents with Chronic Pain.
A1 De la Vega, Rocío
A1 Yokoyama, Kaylee
A1 Daniels, Kristen
A1 Palermo, Tonya M.
K1 Dolor en niños
K1 Psicología social
AB Objective: Reports of pain clinical trials evaluating psychological treatments often lacksufficient details on the potential and actual harm resulting from intervention. We aimedto understand how frequent and intense treatment reactions, conceptualized as unwantedsymptoms, were in three clinical trials of digital cognitive behavioral therapy (CBT) foradolescents with: (1) primary pain, (2) sickle cell, and (3) chronic pancreatitis. We alsoaimed to understand any differences by demographic and clinical variables.Method: Analyses were conducted with 246 youth (12-18 years old) experiencingchronic pain and one of their caregivers. Sixty-six percent of the total sample was female.The number, intensity and type of treatment reactions experienced was assessed at posttreatment. T-tests and Chi-Squares were conducted to explore whether certain treatmentreactions were more frequent as a function of baseline or clinical characteristics.Results: Nine percent of participants experienced some negative treatment reaction. Theaverage intensity of those events was very low on a 0 to 3 scale (M=0.1, SD=0.4). Therewere no differences in prevalence or intensity as a function of participant’s sex, age, raceor baseline pain intensity. However, baseline anxiety (t=-2.4 (244); P<0.05) and baselinepain interference (t=-2.2 (223); P<0.05) were significantly higher in those whoexperienced negative treatment reactions.Conclusions: A small number of participants reported experiencing negative treatmentreactions, with a low intensity level. Those experiencing negative treatment reactionsshowed higher baseline anxiety and pain interference. Future research may build fromour example to standardize collection of harms data in trials of psychologicalinterventions.
PB Oxford University Press
YR 2024
FD 2024
LK https://hdl.handle.net/10630/37974
UL https://hdl.handle.net/10630/37974
LA eng
NO De la Vega, R.; Yokohama, K.; Daniels, K. & Palermo, T.M. (in press). Unwanted or Negative Treatment Reactions in Digital Psychological Interventions for Adolescents with Chronic Pain. Journal of Pediatric Psychology
NO https://openpolicyfinder.jisc.ac.uk/id/publication/1367
NO The work conducted in the included trials was supported by the National Institutesof Health (R21 NR017312), the National Institute of Diabetes and Digestive and KidneyDiseases (NIDDK) Award Number R01DK118752 and U01 DK108334, and the EuniceKennedy Shriver National Institute of Child Health and Human Development of theNational Institutes of Health (R01HD086978). The content is solely the responsibility ofthe authors and does not necessarily represent the official views of the National Institutesof Health. RV’s salary is supported by the Spanish Ministry of Science and Innovationwith a Ramon y Cajal contract (RYC2018-024722-I).
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026