RT Journal Article
T1 Segregation of two glutaminase isoforms in islets of Langerhans.
A1 Baglietto-Vargas, David
A1 López-Téllez, Juan Félix
A1 Moreno-González, Inés
A1 Gutiérrez-Pérez, Antonia
A1 Aledo-Ramos, Juan Carlos
K1 Ácido glutámico
AB Despite the importance of glutamatergic signalling in the co-ordination of hormone secretion, the identity of the enzyme for the production of glutamate in β-cells is still unresolved. We have found that the endocrine pancreas co-expresses two isoforms of GA (glutaminase), denoted as kidney-type (KGA) and liver-type (LGA), with a complementary cellular pattern of expression. Whereas KGA was mainly present in α-cells, LGA was very abundant in β-cells. This spatial segregation may have important functional implications, facilitating a differential regulation of glutamate production in insulin- and glucagon-secreting cells.
PB Portland Press
YR 2004
FD 2004-01-31
LK https://hdl.handle.net/10630/36525
UL https://hdl.handle.net/10630/36525
LA eng
NO Baglietto-Vargas D, López-Téllez JF, Moreno-González I, Gutiérrez A, Aledo JC. Segregation of two glutaminase isoforms in islets of Langerhans. Biochem J. 2004 Jul 15;381(Pt 2):483-7. doi: 10.1042/BJ20040523. PMID: 15089745; PMCID: PMC1133855.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 22 ene 2026