RT Journal Article T1 The role of psychological flexibility and inflexibility in substance addiction, abuse, or misuse: a systematic review and meta‑analysis A1 Barrado-Moreno, Victoria A1 Serrano-Ibáñez, Elena Rocío A1 Esteve-Zarazaga, Rosa A1 Ramírez-Maestre, María del Carmen A1 Sánchez‑Meca, Julio K1 Adaptación (Psicología) K1 Abuso de sustancias - Aspectos psicológicos K1 Adicción - Aspectos psicológicos AB Psychological inflexibility (PI) and psychological flexibility (PF) are transdiagnostic mechanisms involved in the development, maintenance and treatment of SUDs. Evidence on the relationship between their components and substance abuse has not been investigated using a meta-analytic approach. The aim of this meta-analysis was to quantify the association between the dimensions of PF and PI, and substance abuse. A systematic literature review was conducted in four databases. A total of 24 studies were included. The associations were quantified using Pearson’s r correlation coefficients, and two separate meta-analyses were conducted: one for the association between mindfulness and substance abuse, and one for the association between experiential avoidance and substance abuse. The meta-analyses showed a low and negative mindfulness-substance abuse relationship (r = -0.25), and a moderate and positive experiential avoidance-substance abuse relationship (r = 0.34). One study reported a correlation of r = -0.17 between defusion and substance abuse. The search for studies on the remaining components was unsuccessful. Substance type and target population moderated the relationship between mindfulness and substance abuse. Clinical and empirical implications of these results are discussed, and recommendations and future research directions are outlined. PB Springer Nature YR 2025 FD 2025-03-15 LK https://hdl.handle.net/10630/38311 UL https://hdl.handle.net/10630/38311 LA eng NO Barrado-Moreno, V., Serrano-Ibáñez, E.R., Esteve, R. et al. The Role of Psychological Flexibility and Inflexibility in Substance Addiction, Abuse, or Misuse: A Systematic Review and Meta-analysis. Int J Ment Health Addiction (2025). https://doi.org/10.1007/s11469-025-01468-4 NO Funding for open access charge: Universidad de Málaga / CBUA DS RIUMA. Repositorio Institucional de la Universidad de Málaga RD 24 ene 2026