RT Journal Article
T1 Pyroptosis Modulators: New Insights of Gasdermins in Health and Disease.
A1 Allali-Boumara, Imane
A1 Marrero Capitán, Ana Dácil
A1 Rodríguez-Quesada, Ana María
A1 Martínez-Póveda, Beatriz Amparo
A1 Medina-Torres, Miguel Ángel
K1 Proteínas transportadoras
K1 Gasderminas
AB Pyroptosis is an inflammation-dependent type of cell death that has been in the spotlightfor the scientific community in the last few years. Crucial players in the process of pyroptosis are themembers of the gasdermin family of proteins, which have been parallelly studied. Upon inductionof pyroptosis, gasdermins suffer from structural changes leading to the formation of pores in themembrane that subsequently cause the release of pro-inflammatory contents. Recently, it has beendiscovered that oxidation plays a key role in the activation of certain gasdermins. Here, we review thecurrent knowledge on pyroptosis and human gasdermins, focusing on the description of the differentmembers of the family, their molecular structures, and their influence on health and disease directlyor non-directly related to inflammation. Noteworthy, we have focused on the existing understandingof the role of this family of proteins in cancer, which could translate into novel promising strategiesaimed at benefiting human health. In conclusion, the modulation of pyroptosis and gasdermins bynatural and synthetic compounds through different mechanisms, including modification of the redoxstate of cells, has been proven effective and sets precedents for future therapeutic strategies.
PB MDPI
YR 2023
FD 2023-08-03
LK https://hdl.handle.net/10630/31586
UL https://hdl.handle.net/10630/31586
LA eng
NO Allali-Boumara, I., Marrero, A. D., Quesada, A. R., Martínez-Poveda, B., & Medina, M. Á. (2023). Pyroptosis Modulators: New Insights of Gasdermins in Health and Disease. Antioxidants, 12(8), 1551. https://doi.org/10.3390/antiox12081551
NO Partial funding for open access charge: Universidad de Málaga
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 28 feb 2026