RT Journal Article
T1 Concurrence of Iridovirus, Polyomavirus, and a Unique Member of a New Group of Fish Papillomaviruses in Lymphocystis Disease-Affected Gilthead Sea Bream
A1 López-Bueno, Alberto
A1 Mavian, Carla
A1 Labella Vera, Alejandro Manuel
A1 Castro, Dolores
A1 Borrego, Juan José
A1 Alcami, Antonio
A1 Alejo, Alí
K1 Peces - Enfermedades por virus
AB Lymphocystis disease is a geographically widespread disease affecting more than 150 different species of marine and freshwaterfish. The disease, provoked by the iridovirus lymphocystis disease virus (LCDV), is characterized by the appearance of papillomalikelesions on the skin of affected animals that usually self-resolve over time. Development of the disease is usually associatedwith several environmental factors and, more frequently, with stress conditions provoked by the intensive culture conditionspresent in fish farms. In gilthead sea bream (Sparus aurata), an economically important cultured fish species in the Mediterraneanarea, a distinct LCDV has been identified but not yet completely characterized. We have used direct sequencing of the viromeof lymphocystis lesions from affected S. aurata fish to obtain the complete genome of a new LCDV-Sa species that is thelargest vertebrate iridovirus sequenced to date. Importantly, this approach allowed us to assemble the full-length circular genomesequence of two previously unknown viruses belonging to the papillomaviruses and polyomaviruses, termed Sparus auratapapillomavirus 1 (SaPV1) and Sparus aurata polyomavirus 1 (SaPyV1), respectively. Epidemiological surveys showed thatlymphocystis disease was frequently associated with the concurrent appearance of one or both of the new viruses. SaPV1 hasunique characteristics, such as an intron within the L1 gene, and as the first member of the Papillomaviridae family described infish, provides evidence for a more ancient origin of this family than previously thought.
PB ASM Journals
YR 2016
FD 2016-09-12
LK https://hdl.handle.net/10630/33177
UL https://hdl.handle.net/10630/33177
LA eng
NO López-Bueno A, Mavian CLabella AM, Castro D, Borrego JJ, Alcami A, Alejo A. 2016. Concurrence of Iridovirus, Polyomavirus, and a Unique Member of a New Group of Fish Papillomaviruses in Lymphocystis Disease-Affected Gilthead Sea Bream. J Virol 90:. https://doi.org/10.1128/jvi.01369-16
NO This work, including the efforts of Juan J. Borrego, was funded by Juntade Andalucia (P12-RNM-2261). This work, including the efforts of Al berto López-Bueno, was funded by Ministerio de Economía y Competi tividad (RYC-2010-06300). This work, including the efforts of AlíAlejo, was funded by Ministerio de Economía y Competitividad(AGL2009-08711).
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 22 ene 2026