RT Journal Article
T1 Metabolite-Driven Modulation of Biofilm Formation in Shewanella: Insights from Shewanella sp. Pdp11 Extracellular Products
A1 Pérez-Gómez, Olivia
A1 Domínguez-Maqueda, Marta
A1 García-Márquez, Jorge
A1 Moriñigo-Gutiérrez, Miguel Ángel
A1 Tapia-Paniagua, Silvana Teresa
K1 Bacterias
K1 Metabolitos
AB Biofilm formation is a survival strategy for bacteria, contributing to their persistence in natural and industrial environments. In this study, we investigated the ability of extracellular products (ECPs) produced by the probiotic strain Shewanella sp. Pdp11 under different culture conditions to inhibit biofilm formation in pathogenic and environmental Shewanella strains. ECPs from specific culture conditions altered biofilm formation in several Shewanella strains, with Shewanella hafniensis P14 displaying the highest sensitivity. Metabolomic analysis of the ECPs identified glycogen as a key metabolite associated with biofilm inhibition. Further genomic analysis of S. hafniensis P14 revealed an interruption in its glycogen synthesis pathway, suggesting a dependency on external glycogen-related metabolites for biofilm development. These findings demonstrate that Shewanella sp. Pdp11 ECPs can modify biofilm formation across multiple Shewanella strains, particularly in S. hafniensis P14 through glycogen-associated mechanisms.
PB Springer Nature
YR 2025
FD 2025-01-28
LK https://hdl.handle.net/10630/38770
UL https://hdl.handle.net/10630/38770
LA eng
NO Pérez-Gómez, O., Domínguez-Maqueda, M., García-Márquez, J. et al. Metabolite-Driven Modulation of Biofilm Formation in Shewanella: Insights from Shewanella sp. Pdp11 Extracellular Products. Microb Ecol 88, 55 (2025). https://doi.org/10.1007/s00248-025-02552-x
NO Funding for open access publishing: Universidad de Málaga/CBUA and Ministerio de Ciencia e Innovación PID2020-113637RB-C21, PID2020-113637RB-C22.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026