RT Journal Article
T1 Novel Insights into the Molecular Mechanisms Governing Embryonic Epicardium Formation.
A1 Carmona-Mejías, Rita María
A1 López-Sánchez, Carmen
A1 García-Martínez, Virginio
A1 García-López, Virginio
A1 Muñoz-Chápuli-Oriol, Ramón
A1 Lozano-Velasco, Estefanía
A1 Franco, Diego
K1 Transcripción genética - Regulación
K1 Corazón - Embriología
AB The embryonic epicardium originates from the proepicardium, an extracardiac primordiumconstituted by a cluster of mesothelial cells. In early embryos, the embryonic epicardium is characterizedby a squamous cell epithelium resting on the myocardium surface. Subsequently, it invades thesubepicardial space and thereafter the embryonicmyocardiumbymeans of an epithelial–mesenchymaltransition.Within the myocardium, epicardial-derived cells present multilineage potential, later differentiatinginto smoothmuscle cells and contributing both to coronary vasculature and cardiac fibroblastsin themature heart. Over the last decades, we have progressively increased our understanding of thosecellular and molecular mechanisms driving proepicardial/embryonic epicardium formation. Thisstudy provides a state-of-the-art review of the transcriptional and emerging post-transcriptionalmechanisms involved in the formation and differentiation of the embryonic epicardium.
PB MDPI
YR 2023
FD 2023
LK https://hdl.handle.net/10630/38982
UL https://hdl.handle.net/10630/38982
LA eng
NO Carmona, R.; López- Sánchez, C.; Garcia-Martinez, V.; Garcia-López, V.; Muñoz-Chápuli, R.; Lozano-Velasco, E.; Franco, D. Novel Insights into the Molecular Mechanisms Governing Embryonic Epicardium Formation. J. Cardiovasc. Dev. Dis. 2023, 10, 440. https:// doi.org/10.3390/jcdd10110440
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 12 abr 2026