RT Journal Article
T1 Soluble Receptor Isoform of IFN-Beta (sIFNAR2) in Multiple Sclerosis Patients and Their Association With the Clinical Response to IFN-Beta Treatment
A1 Aliaga-Gaspar, Pablo
A1 Hurtado-Guerrero, Isaac
A1 Ciano-Petersen, Nicolas Lundahl
A1 Urbaneja, Patricia
A1 Brichette Mieg, Isabel
A1 Virginia Reyes, Virginia
A1 Rodríguez-Bada, José Luis
A1 Alvarez-Lafuente, Roberto
A1 Arroyo, Rafael
A1 Quintana, Ester
A1 Ramió-Torrentà, Lluis
A1 Alonso, Ana
A1 Leyva-Fernández, Laura
A1 Fernández-Fernández, Óscar
A1 Oliver-Martos, Begoña
K1 Receptores - Efectos de los medicamentos
K1 Interferón
AB Protein and mRNA levels of sIFNAR2 increased after IFN-b treatment. According to the clinical response, only non-responders increased sIFNAR2 significantly at both protein and mRNA levels. sIFNAR2 gene expression correlated with the transmembraneisoform expression and was 2.3-fold higher. While MxA gene expression increased significantly after treatment, IFNAR1 and IFNAR2 only slightly increased. After short-term IFN-b in vitro induction of PBMC, 6/7 patients increased the sIFNAR2 expression.IFN-b administration induces the production of sIFNAR2 in RRMS and higher levels might be associated to the reduction of therapeutic response. Thus, levels of sIFNAR2 could be monitored to optimize an effective response to IFN-b therapy.
PB Frontiers
YR 2021
FD 2021-12
LK https://hdl.handle.net/10630/33722
UL https://hdl.handle.net/10630/33722
LA eng
NO This research was funded by grants from the Instituto de Salud Carlos III and co-funded by European Regional Development Fund (ERDF), Technological Development Project in health DTS/ 1800045 to BO-M. BO-M holds a contract from Red Andaluza de Investigacion Clınica y Traslacional en Neurolog ́ ıa (Neuro-reca) ́ (RIC-0111-2019). PA-G is supported by Promoción de Empleo Joven e Implantación de la Garantıa Juvenil 2018 (PEJ2018-002719- ́A). JR-B is supported by grantsfrom Red Temática de Investigación Cooperativa, Red Española de Esclerosis Multiple REEM (RD16/0015/0010). LL holds a Nicolá s Monardes research contract (RC002-2019) from the Andalusian Ministry of Health and Family. IBM holds a pFIS contract (FI19/00139)from the Spanish Science and Innovation Ministry.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 21 ene 2026