RT Journal Article
T1 ER-plastid contact sites as molecular crossroads for plastid lipid biosynthesis
A1 Huércano, Carolina
A1 Moya-Barrientos, Miriam
A1 Cuevas Corral, Oliver
A1 Sánchez-Vera, Victoria
A1 Ruiz-López, Noemí
K1 Membranas (Biología)
K1 Lípidos de membrana
K1 Retículo endoplásmico
AB Membrane contact sites are specialized regions where organelle membranes are in close proximity, enabling lipid transfer while preserving membrane identity. In plants, ER‒chloroplast contact sites are critical for maintaining glycerolipid homeostasis. This review examines the lipid-modifying and lipid-transfer proteins/complexes involved in these processes. Key proteins at these sites, including components of the TGD and VAP27‒ORP2A complexes, as well as Sec14 proteins, facilitate lipid exchange. Additionally, the roles of lipid-modifying proteins at these contact sites are discussed. Despite significant progress, further research is needed to identify additional proteins, investigate ER‒chloroplast dynamics under stress and explore ER contact sites in non-chloroplast plastids.
PB BioMed Central
YR 2025
FD 2025-05-22
LK https://hdl.handle.net/10630/38941
UL https://hdl.handle.net/10630/38941
LA eng
NO Huercano C, Moya-Barrientos M, Cuevas O, Sanchez-Vera V, Ruiz-Lopez N. ER-plastid contact sites as molecular crossroads for plastid lipid biosynthesis. BMC Biol. 2025 May 22;23(1):139. doi: 10.1186/s12915-025-02239-2. PMID: 40405194; PMCID: PMC12096540.
NO This work was mostly supported by grant PID2021-127649OB-I00, funded by MCIN/AEI/10.13039/501100011033 and the European Union/FEDER, awarded to N.R.L., and by the predoctoral fellowship PRE2019-087710, awarded to C.H and funded through project PGC-2018-098789-B-I00 (MCIN/AEI/10.13039/501100011033) also awarded to N.R.L. Additional support was provided by grant PID2020-120227RJ-I00, funded by MCIN/AEI/10.13039/501100011033, and by the “ESF+” grant RYC2023- 044355-I, awarded to V.S-V. This work was also supported by grant A.3.1 from the II Plan Propio de Investigación, Transferencia y Divulgación Científica of the Universidad de Málaga, awarded to C.H.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026