RT Conference Proceedings
T1 Thermorresponsive magnetic nanoparticles as target drug delivery for cancer treatment
A1 Ortega Rodríguez, Alicia
A1 Porras Alcalá, Cristina
A1 Contreras-Cáceres, Rafael
A1 López-Romero, Juan Manuel
A1 Melguizo, Consolación
A1 Prados, José Carlos
K1 Nanopartículas - Toxicología
K1 Nanopartículas - Uso en diagnóstico
AB In this research, temperature sensitive microgels with magnetic core for controlled release of 5-fluoruracil was synthesized. Magnetic nanoparticles (Fe3O4) were prepared by coprecipitation method and the surface was functionalized by acrylic acid.  Polymer poly(N-isopropylacrylamide) (PNIPAM) were grown by free radical polymerization in presence of cross-liker and initiator. The size of the polymer was manipulated by changing the mole percent of the crosslinker and evaluated for their morphology (TEM), particle size, zeta potential, loading efficiency, drug content and drug release. Furthermore, microgels were tagged with FITC, a fluorochrome which could be applied for cell imaging.  Cytotoxicity studies revealed that the microgels were not toxic. These complex nanoparticles (Fe3O4/pNIPAM/FITC/5-Fu) appear to be a great promise to be used in controlled drug delivery and tumor targeting.
YR 2019
FD 2019-05-15
LK https://hdl.handle.net/10630/17658
UL https://hdl.handle.net/10630/17658
LA eng
NO Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 25 ene 2026