RT Conference Proceedings
T1 Relationship between chronological aging and acquired resistance to cisplatin in the yeast saccharomyces cerevisiae
A1 Burgos-Molina, Antonio Manuel
A1 Mercado-Sáenz, Silvia
A1 Gil-Carmona, Luisa
A1 Ruiz-Gómez, Miguel José
K1 Envejecimiento
AB The Sir2 gene is associated with an increase in longevity in yeasts, worms, flies and rodents. The human homolog, Sirt1, is also involved in longevity, by inhibiting cellular senescence. Studies carry out in tumor cells of neuroblastoma, osteosarcoma, breast and ovary, resistant and sensitive to antineoplastic drugs, suggest that the increase of Sirt1 expression may represent a general phenomenon associated with resistance to chemotherapy, independent of cell type or drug used to induce resistance. Thus, after analyzing tumor biopsies after treating patients with chemotherapy, high amounts of Sirt1 have been observed.The aim of this work is to study the relationship between chronological aging and acquired resistance to Cisplatin in the yeast Saccharomyces cerevisiae.
YR 2019
FD 2019-01-17
LK https://hdl.handle.net/10630/17169
UL https://hdl.handle.net/10630/17169
LA eng
NO Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026