RT Journal Article
T1 Postbiotic Dietary Supplementation with Sonicated Shewanella sp. SpPdp11 Improves Intestinal Status in Juvenile Senegalese Sole (Solea senegalensis)
A1 Cerezo, I.M.
A1 Delgado-Martín, B.
A1 Vizcaíno, A.J.
A1 Galafat, A.
A1 Alarcón-López, F.J.
A1 García de la Banda, I.
A1 Hernández de Rojas, A.
A1 Díaz, L
A1 Balebona-Accino, María del Carmen
A1 Tapia-Paniagua, Silvana Teresa
A1 Moriñigo-Gutiérrez, Miguel Ángel
K1 Microbiología
K1 Intestinos - Salud
K1 Inflamación (Patología)
K1 Acuicultura
AB The use of non-viable microbial preparations (postbiotics) is emerging as a safe alternative to probiotics in aquaculture.In this study, we investigated the impact of dietary inclusion of sonicated cells of the marine bacterium Shewanella sp.Pdp11 (SpPdp11) on the intestinal health of juvenile Senegalese sole (Solea senegalensis). Fish were fed a control dietor a diet supplemented with SpPdp11 postbiotic for 45 days, and their intestinal status was assessed using histological,transcriptomic, and microbiota analyses. Postbiotic supplementation improved intestinal morphology by widening villi andreducing lamina propria and epithelial height, suggesting enhanced barrier function. RNA-seq analysis revealed downregulation of inflammatory pathways, including ECM receptor interaction and PPAR signaling, together with activation ofbile acid biosynthesis. 16 S rRNA profiling showed a marked shift in microbial composition, with decreased prevalenceof opportunistic taxa such as Vibrio and Stenotrophomonas and enrichment of beneficial genera, including Acinetobacter,Pseudomonas, and Malacoplasma. These results provide evidence that marine-derived postbiotics can modulate hostphysiology and gut microbial communities without the risks associated with live probiotics. Sonicated SpPdp11 representsa promising biotechnological feed additive to support intestinal health, reduce inflammation, and promote sustainableaquaculture practices
PB Springer
YR 2026
FD 2026-04-14
LK https://hdl.handle.net/10630/46404
UL https://hdl.handle.net/10630/46404
LA eng
NO Cerezo, I., Delgado-Martín, B., Vizcaíno, A. et al. Postbiotic Dietary Supplementation with Sonicated Shewanella sp. SpPdp11 Improves Intestinal Status in Juvenile Senegalese Sole (Solea senegalensis). Mar Biotechnol 28, 62 (2026). https://doi.org/10.1007/s10126-026-10608-3
NO Funding for open access charge: Universidad de Málaga/CBUA. This study was supported by grants from the I + D+Ì projects Framework FEDER Andalucía 2014–2020 Operational Program 2020 (UMA20-FEDERJA-016) and Ministerio de Economía y Competitividad (MINECO) (PID2020-113637RB-C22).
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 4 may 2026