RT Journal Article
T1 Synergistic effect of Si-hydroxyapatite coating and VEGF adsorption on Ti6Al4V-ELI scaffolds for bone regeneration in an osteoporotic bone environment
A1 Izquierdo-Barba, Isabel
A1 Santos-Ruiz, Leonor
A1 Becerra-Ratia, José
A1 Feito, M.J.
A1 Fernández-Villa, D.
A1 Serrano, M.C.
A1 Díaz-Güemes, I.
A1 Fernández-Tomé, B.
A1 Enciso, S.
A1 Sánchez-Margallo, F.M.
A1 Monopoli, Donato
A1 Alfonso, H.
A1 Portolés, María Teresa
A1 Arcos, Daniel
A1 Vallet-Regí, M.
K1 Huesos - Crecimiento
AB The osteogenic and angiogenic responses to metal macroporous scaffolds coated with silicon substituted hydroxyapatite (SiHA) and decorated with vascular endothelial growth factor (VEGF) have been evaluated in vitro and in vivo. Ti6Al4V-ELI scaffolds were prepared by electron beam melting and subsequently coated with Ca-10(PO4)(5.6)(SRO4)(0.4)(OH)(1.6) following a dip coating method. In vitro studies demonstrated that SiHA stimulates the proliferation of MC3T3-E1 pre-osteoblastic cells, whereas the adsorption of VEGF stimulates the proliferation of EC2 mature endothelial cells. In vivo studies were carried out in an osteoporotic sheep model, evidencing that only the simultaneous presence of both components led to a significant increase of new tissue formation in osteoporotic bone.
PB Elsevier
YR 2019
FD 2019-01-01
LK https://hdl.handle.net/10630/29669
UL https://hdl.handle.net/10630/29669
LA eng
NO MINECO (MAT2015-64831-R, MAT2016-75611-R AEI/FEDER, UE y BI02015-66266-R)Institute de Salud Carlos III (RD12-0019-0032)European Research Council (Advanced Grant VERDI; ERC-2015-AdG Proposal 694160)
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 21 ene 2026