RT Journal Article
T1 Schwann cells: Rescuers of central demyelination
A1 Garcia Diaz, Beatriz
A1 Baron Van Evercooren, Anne
K1 Sistema nervioso central
AB The presence of peripheral myelinating cells in the central nervous system (CNS) hasgained the neurobiologist attention over the years. Despite the confirmed presence ofSchwann cells in the CNS in pathological conditions, and the long list of their beneficialeffects on central remyelination, the cues that impede or allow Schwann cells to success-fully conquer and remyelinate central axons remain partially undiscovered. A betterknowledge of these factors stands out as crucial to foresee a rational therapeuticapproach for the use of Schwann cells in CNS repair. Here, we review the diverse originsof Schwann cells into the CNS, both peripheral and central, as well as the CNS compo-nents that inhibit Schwann survival and migration into the central parenchyma. Namely,we analyze the astrocyte- and the myelin-derived components that restrict Schwanncells into the CNS. Finally, we highlight the unveiled mode of invasion of these peripheralcells through the central environment, using blood vessels as scaffolds to pave their waystoward demyelinated lesions. In short, this review presents the so far uncovered knowl-edge of this complex CNS-peripheral nervous system (PNS) relationship
PB Wiley
YR 2020
FD 2020
LK https://hdl.handle.net/10630/32330
UL https://hdl.handle.net/10630/32330
LA eng
NO Garcia-Diaz B, Baron-VanEvercooren A. Schwann cells: Rescuers of centraldemyelination. Glia. 2020;68:1945–1956. https://doi.org/10.1002/glia.237881956
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026