RT Journal Article
T1 Comparison of an Energy-Reduced Mediterranean Diet and Physical Activity Versus an Ad Libitum Mediterranean Diet in the Prevention of Type 2 Diabetes.
A1 Ruiz-Canela, Miguel
A1 Corella, Dolores
A1 Martínez González, Miguel Ángel
A1 Babio, Nancy
A1 Martínez, J. Alfredo
A1 Forga, Luis
A1 Alonso-Gómez, Ángel M.
A1 Warnberg, Julia
A1 Vioque, Jesús
A1 Romaguera, Dora
A1 López-Miranda, José
A1 Estruch, Ramón
A1 Santos-Lozano, José Manuel
A1 Serra-Majem, Luis
A1 Bueno-Cavanillas, Aurora
A1 Tur, Josep A.
A1 Martín-Sánchez, Vicente
A1 Riera-Mestre, Antoni
A1 Delgado-Rodríguez, Miguel
A1 Matía-Martín, Pilar
A1 Vidal, Josep
A1 Vázquez, Clotilde
A1 Daimiel, Lidia
A1 Buil-Cosiales, Pilar
A1 Shyam, Sangeetha
A1 Sorlí, José V.
A1 Castañer, Olga
A1 García-Rios, Antonio
A1 Torres-Collado, Laura
A1 Gómez-Gracia, Enrique
A1 Zulet, M. Ángeles
A1 Konieczna, Jadwiga
A1 Casas, Rosa
A1 Cano-Ibáñez, Naomi
A1 Tojal-Sierra, Lucas
A1 Bernal-López, Rosa M.
A1 Toledo, Estefanía
A1 García-Gavilán, Jesús F.
A1 Fernández-Carrión, Rebeca
A1 Goday, Albert
A1 Arenas-Larriva, Antonio P.
A1 González-Palacios, Sandra
A1 Schröder, Helmut
A1 Ros, Emilio
A1 Fitó, Montserrat
A1 Hu, Frank B.
A1 Tinahones-Madueño, Francisco José
A1 Salas-Salvadó, Jordi
K1 Medicina preventiva
K1 Diabetes tipo 2 - Prevención
K1 Alimentación - Mediterráneo (Región)
AB Prespecified secondary outcome analysis in the PREDIMED (Prevención con Dieta Mediterránea) Plus randomized, single-blinded, controlled trial. (ISRCTN Registry: ISRCTN89898870) Setting: 23 centers across Spain. Participants: 4746 adults aged 55 to 75 years with metabolic syndrome and overweight or obesity, without prior cardiovascular disease or diabetes. Participants were randomly assigned 1:1 to an intervention group receiving an erMedDiet (planned reduction of 600 kcal per day), increased physical activity, and behavioral strategies for reducing weight, or a control group receiving ad libitum MedDiet advice. Results: During the 6-year intervention period, absolute risk was 12.8% (95% CI, 11.0% to 14.5%) in the control group and 10.3% (CI, 8.8% to 11.8%) in the intervention group; the absolute risk reduction was 2.5% (CI,  4.7% to  0.3%); and the adjusted Hazard ratio was 0.67 (CI, 0.56 to 0.80). When the extended follow-up period beyond the intervention period (range between more than 6 years and 8.6 years) was included, diabetes incidence was 31% (CI, 18% to 41%) relatively lower in the intervention group (280 cases) compared with the control group (349 cases). Limitation: Secondary outcome, single-blinded design, and self-reported dietary adherence. Conclusion: An intensive intervention with the MedDiet adding caloric reduction, physical activity, and modest weight loss was more effective than only an ad libitum MedDiet in reducing diabetes incidence in overweight/ obese persons with metabolic syndrome
PB American College of Physicians (ACP)
YR 2025
FD 2025-10-01
LK https://hdl.handle.net/10630/44756
UL https://hdl.handle.net/10630/44756
LA eng
NO Ruiz-Canela M, Corella D, Martínez-González MÁ, Babio N, Martínez JA, Forga L, Alonso-Gómez ÁM, Wärnberg J, Vioque J, Romaguera D, López-Miranda J, Estruch R, Santos-Lozano JM, Serra-Majem L, Bueno-Cavanillas A, Tur JA, Martín-Sánchez V, Riera-Mestre A, Delgado-Rodríguez M, Matía-Martín P, Vidal J, Vázquez C, Daimiel L, Buil-Cosiales P, Shyam S, Sorlí JV, Castañer O, García-Rios A, Torres-Collado L, Gómez-Gracia E, Zulet MÁ, Konieczna J, Casas R, Cano-Ibáñez N, Tojal-Sierra L, Bernal-López RM, Toledo E, García-Gavilán J, Fernández-Carrión R, Goday A, Arenas-Larriva AP, González-Palacios S, Schröder H, Ros E, Fitó M, Hu FB, Tinahones FJ, Salas-Salvadó J. Comparison of an Energy-Reduced Mediterranean Diet and Physical Activity Versus an Ad Libitum Mediterranean Diet in the Prevention of Type 2 Diabetes : A Secondary Analysis of a Randomized Controlled Trial. Ann Intern Med. 2025 Oct;178(10):1378-1389. doi: 10.7326/ANNALS-25-00388. Epub 2025 Aug 26. PMID: 40854218.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 4 mar 2026