RT Journal Article
T1 Distinct phenotype of hepatotoxicity associated with illicit use of anabolic androgenic steroids.
A1 Robles-Díaz, María Mercedes
A1 González-Jiménez, Andrés
A1 Medina-Cáliz, Inmaculada
A1 Stephens, Camilla
A1 García-Cortés, Miren
A1 García-Muñoz, B
A1 Ortega-Alonso, Aida
A1 Blanco-Reina, Encarnación
A1 González-Grande, Rocío
A1 Jiménez-Pérez, Miguel
A1 Rendón, P
A1 Navarro, JM
A1 Gines, P
A1 Prieto, M
A1 Garcia-Eliz, M
A1 Bessone, Fernando
A1 Brahm, JR
A1 Paraná, R
A1 Lucena-González, María Isabel
A1 Andrade-Bellido, Raúl Jesús
K1 Hepatotoxicidad
K1 Hígado - Heridas y lesiones
K1 Anabolizantes - Toxicidad
AB Background: We have observed an increase in hepatotoxicity (DILI) reporting related tothe use of anabolic androgenic steroids (AAS) for bodybuilding.Aim: To characterise phenotype presentation, outcome and severity of AAS DILI.Methods: Data on 25 cases of AAS DILI reported to the Spanish (20) and Latin- American(5) DILI Registries were collated and compared with previously published cases.Results: AAS DILI increased from representing less than 1% of the total cases in theSpanish DILI Registry in the period 2001–2009 to 8% in 2010–2013. Young men (meanage 32 years), requiring hospitalisation, hepatocellular injury and jaundice werepredominating features among the AAS cases. AAS DILI caused significantly higherbilirubin values independent of type of damage when compared to other drug classes (P= 0.001). Furthermore, the cholestatic AAS cases presented significantly higher meanpeak bilirubin (P = 0.029) and serum creatinine values (P = 0.0002), compared to thehepatocellular cases. In a logistic regression model, the interaction between peak bilirubinvalues and cholestatic damage was associated with the development of AAS-inducedacute kidney impairment (AKI) [OR 1.26 (95% CI: 1.035–1.526); P = 0.021], with 21.5×ULN being the best bilirubin cut- off point for predicting AKI risk (AUCROC 0.92). Nofatalities occurred.
AB Conclusions: Illicit recreational AAS use is a growing cause of reported DILI that canlead to severe hepatic and renal injury. AAS DILI is associated with a dis- tinctphenotype, characterised by considerable bilirubin elevations indepen- dent of type ofdamage. Although hepatocellular injury predominates, acute kidney injury develops incholestatic cases with pronounced jaundice.
PB Wiley
YR 2015
FD 2015-01
LK https://hdl.handle.net/10630/40272
UL https://hdl.handle.net/10630/40272
LA eng
NO M Robles-Diaz, A Gonzalez-Jimenez, I Medina-Caliz, C Stephens, M García-Cortes, B García-Muñoz, A Ortega-Alonso, E Blanco-Reina, R Gonzalez-Grande, M Jimenez-Perez, P Rendón, JM Navarro, P Gines†, M Prieto, M Garcia-Eliz, F Bessone, JR Brahm, R Paran´a, MI Lucena, RJ Andrade, on behalf of the Spanish DILI Registry & the SLatinDILI Network. Distinct phenotype of hepatotoxicity associated with illicit use of anabolic androgenic steroids. Aliment Pharmacol Ther 2015 Jan;41(1):116-125
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 21 ene 2026