RT Journal Article
T1 Galanin (1–15)-fluoxetine interaction in the novel object recognition test. Involvement of 5-HT1A receptors in the prefrontal cortex of the rats
A1 Flores-Burgess, Antonio
A1 Millón-Peñuela, Carmelo
A1 Gago-Calderón, Belén
A1 García-Durán, Laura
A1 Coveñas, Rafael
A1 Narváez-Bueno, José Ángel
A1 Fuxe, Kjell
A1 Santín-Núñez, Luis Javier
A1 Díaz-Cabiale, Zaida
K1 Corteza cerebral - Reconocimiento
AB Galanin (1-15) [GAL(1–15)] participates in mood regulation and depression. GAL(1–15) is also able to enhance the antidepressant effects induced by Fluoxetine (FLX) in the forced swimming test through interaction between GALR1-GALR2 and 5-HT1A receptors that induced changes in the binding characteristics and mRNA of the 5-HT1AR in the hippocampus.Since the medial prefrontal cortex (mPFC) is a core region for the interaction between emotional processing and cognition with a high density of 5-HT1AR and GALR1 and GALR2, we have analyzed the binding characteristics and mRNA levels of 5-HT1AR in the mPFC after GAL(1–15)-FLX administration in the rats. GAL(1–15) increased the Kd and the Bmax of the 5HT1AR agonist binding in the mPFC as well as the mRNA levels of 5-HT1AR in mPFC. Moreover, GAL(1–15) reversed the effects of memory impairment induced by FLX(10 mg/kg) in the Novel Object Recognition task. GALR2 was involved in these effects, since the specific GALR2 antagonist M871 blocked GAL(1–15) mediated actions at behavioral level. On the contrary GAL(1–15) did not reverse the effect of FLX in the Object Location Memory task.In conclusion, our results describe an interactions between GAL(1–15) and FLX in the mPFC involving interactions at the 5-HT1AR receptor level in the plasma membrane with changes at the transcriptional level with implications also at functional level. The GALR1-GALR2-5-HT1A heteroreceptor could be postulated to be used to reverse some of the adverse effects of FLX on memory processes.
PB Elsevier
YR 2019
FD 2019
LK https://hdl.handle.net/10630/37092
UL https://hdl.handle.net/10630/37092
LA eng
NO Antonio Flores-Burgess, Carmelo Millón, Belen Gago, Laura García-Durán, Noelia Cantero-García, Rafael Coveñas, José Angel Narváez, Kjell Fuxe, Luis Santín, Zaida Díaz-Cabiale, Galanin (1–15)-fluoxetine interaction in the novel object recognition test. Involvement of 5-HT1A receptors in the prefrontal cortex of the rats, Neuropharmacology, Volume 155, 2019, Pages 104-112, ISSN 0028-3908, https://doi.org/10.1016/j.neuropharm.2019.05.023. (https://www.sciencedirect.com/science/article/pii/S0028390819301789)
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 21 ene 2026