RT Conference Proceedings
T1 Acute psychological stress: effects on hippocampal neurogenesis and the role of microglia
A1 Nieto-Quero, Andrea
A1 Chaves-Peña, Patricia
A1 Infantes-López, M. Inmaculada
A1 Zambrana-Infantes, Emma
A1 Tabbai-Amal, Sara
A1 Muñoz-Martín, José
A1 Pérez-Martín, Margarita
A1 Pedraza-Benítez, María del Carmen
K1 Neurobiología del desarrollo
K1 Microglia
K1 Estrés (Fisiología)
AB Among all the factors that can contribute to the onset of psychopathological disorders,stress is the main environmental factor. The hippocampus is one of the most sensitiveregions to the harmful effects of stress, in which the neurogenic process is impaired. Onthe other hand, under stress situations, microglia are also affected and can trigger aproinflammatory response, acting as anti-neurogenic cells and releasing cytokines andother proinflammatory molecules. Knowing what happens in the early stages of stressmay be relevant to investigate the temporal aspects of the development of stressassociatedpsychopathological disorders, and even their possible treatment. Therefore,after subjecting C57BL/6J mice for 2 hours to an acute and intense stress procedure calledWIRS (water immersion restraint stress), data were analyzed to study microglia, cellproliferation and neuronal maturation. In addition, a mediation analysis study wasconducted for data integration. The results revealed that the applied acute stress issufficiently intense to induce an increase in the number of microglia, accompanied bymorphometric changes, as well as negatively affecting the neuronal maturational process.Furthermore, these data suggest that effects on the neurogenic process mediate themicroglial response to an intense acute stressor. This leads to the conclusion that this maybe the initial mechanism for any intense stress response, or may even be the first steps inthe development of the response to a chronic stressor.
YR 2022
FD 2022
LK https://hdl.handle.net/10630/24792
UL https://hdl.handle.net/10630/24792
LA spa
NO Ministerio de Ciencia e Innovación – Plan Nacional I+D+i from Spain: PID2020-117464RB-I00 to C. Pedraza and M. Pérez-Martín- FEDER/Ministerio de Ciencia e Innovación – Agencia Estatal de Investigación fromSpain: PSI2017-83408-P to C. Pedraza-- FEDER/Junta de Andalucía – Proyectos I+D+I en el marco del Programa OperativoFEDER Andalucía 2014-2020: UMA20-FEDERJA-112 to C. Pedraza and M. Pérez-Martín- Consejería de Conocimiento, Investigación y Universidades, Junta de Andalucía:P20_00460 to C. Pedraza- Contract in charge of the project P20_00460 to P. Chaves-Peña- Ministerio de Universidades from Spain: FPU16/05308 to A. Nieto-Quero andFPU19/03629 to M.I. Infantes-López- I Plan Propio de Investigación, Transferencia y Divulgación Científica (convocatoria2021) from University of Malaga: predoctoral fellowship to J. Munoz-Martin.II Plan Propio de Investigación, Transferencia y Divulgación Científica; Universidad de Málaga.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 26 ene 2026