RT Journal Article
T1 IL2RA/CD25 gene polymorphisms: uneven association with multiple sclerosis (MS) and type 1 diabetes (T1D).
A1 Alcina, Antonio
A1 Fedetz, María
A1 Ndagire, Dorothy
A1 Fernández Fernández, Óscar
A1 Leyva-Fernández, Laura
A1 Guerrero, Miguel
A1 Abad-Grau, María del Mar
A1 Arnal, Carmen
A1 Delgado, Concepción
A1 Lucas, Miguel
A1 Izquierdo, Guillermo
A1 Matesanz, Fuencisla
K1 Diabetes
K1 Esclerosis múltiple
AB Background:IL-2 receptor (IL2R) alpha is the specific component of the high affinity IL2R system involved in the immune response and in the control of autoimmunity.Methods and Results: Here we perform a replication and fine mapping of the IL2RA gene region analyzing 3 SNPs previously associated with multiple sclerosis (MS) and 5 SNPs associated with type 1 diabetes (T1D) in a collection of 798 MS patients and 927 matched Caucasian controls from the south of Spain. We observed association with MS in 6 of 8 SNPs. The rs1570538, at the 39- UTR extreme of the gene, previously reported to have a weak association with MS, is replicated here (P = 0.032). The most associated T1D SNP (rs41295061) was not associated with MS in the present study. However, the rs35285258, belonging to another independent group of SNPs associated with T1D, showed the maximal association in this study but different risk allele. We replicated the association of only one (rs2104286) of the two IL2RA SNPs identified in the recently performed genome-wide association study of MS.Conclusions:These findings confirm and extend the association of this gene with MS and reveal a genetic heterogeneity of the associated polymorphisms and risk alleles between MS and T1D suggesting different immunopathological roles of IL2RA in these two diseases.
PB Public Library of Science
YR 2009
FD 2009
LK https://hdl.handle.net/10630/32308
UL https://hdl.handle.net/10630/32308
LA eng
NO Alcina A, Fedetz M, Ndagire D, Fernández O, Leyva L, Guerrero M, Abad-Grau MM, Arnal C, Delgado C, Lucas M, Izquierdo G, Matesanz F. IL2RA/CD25 gene polymorphisms: uneven association with multiple sclerosis (MS) and type 1 diabetes (T1D). PLoS One. 2009;4(1):e4137. doi: 10.1371/journal.pone.0004137. Epub 2009 Jan 6. PMID: 19125193; PMCID: PMC2607550
NO Versión publicada del artículo
NO Financial support for the study was provided by the Ministerio de Educacio´n y Ciencia (grants PN-SAF2006-02023 and TIN2007-67418-C03-03) and Junta de Andaluc´ıa (P07-CVI-02551) to A. Alcina and Servicio Andaluz de Salud de la Junta de Andaluc´ıa (grant PI0168/2007) to F. Matesanz. Mar´ıa Fedetz is a holder of a fellowship from Fundacio´n IMABIS. Dorothy Ndagire is a holder of AECI-Ministerio de Asuntos Exteriores fellowship. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026