RT Journal Article
T1 A Bacterial Effector Protein Hijacks Plant Metabolism to Support Pathogen Nutrition.
A1 Xian, Liu
A1 Yu, Gang
A1 Wei, Yali
A1 Rufián Plaza, José Sebastián
A1 Li, Yansha
A1 Zhuang, Haiyan
A1 Xue, Hao
A1 Morcillo, Rafael J
A1 Macho, Alberto P
K1 Plantas - Metabolismo
K1 Bacterias fitopatógenas
AB Many bacterial plant pathogens employ a type III secretion system to inject effector proteins within plant cells to suppress plant immunity. Whether and how effector proteins also co-opt plant metabolism to support extensive bacterial replication remains an open question. Here, we show that Ralstonia solanacearum, the causal agent of bacterial wilt disease, secretes the effector protein RipI, which interacts with plant glutamate decarboxylases (GADs) to alter plant metabolism and support bacterial growth. GADs are activated by calmodulin and catalyze the biosynthesis of gamma-aminobutyric acid (GABA), an important signaling molecule in plants and animals. RipI promotes the interaction of GADs with calmodulin, enhancing the production of GABA. R. solanacearum is able to replicate efficiently using GABA as a nutrient, and both RipI and plant GABA contribute to a successful infection. This work reveals a pathogenic strategy to hijack plant metabolism for the biosynthesis of nutrients that support microbial growth during plant colonization.
PB Cell Press
YR 2020
FD 2020
LK https://hdl.handle.net/10630/32489
UL https://hdl.handle.net/10630/32489
LA eng
NO Xian L, Yu G, Wei Y, Rufian JS, Li Y, Zhuang H, Xue H, Morcillo RJL, Macho AP. A Bacterial Effector Protein Hijacks Plant Metabolism to Support Pathogen Nutrition. Cell Host Microbe. 2020 Oct 7;28(4):548-557.e7. doi: 10.1016/j.chom.2020.07.003. Epub 2020 Jul 30.
NO Política de acceso abierto tomada de: https://v2.sherpa.ac.uk/id/publication/6581
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026