RT Journal Article
T1 Danthron, an Anthraquinone Isolated from a Marine Fungus, Is a New Inhibitor of Angiogenesis Exhibiting Interesting Antitumor and Antioxidant Properties
A1 Vidal-Valenzuela, Isabel
A1 Torres-Vargas, José Antonio
A1 Sánchez López, José María
A1 Trigal Martínez, Mónica
A1 García-Caballero, Melissa
A1 Medina-Torres, Miguel Ángel
A1 Rodríguez-Quesada, Ana María
K1 Antiangiogénicos
K1 Cáncer - Prevención
K1 Tumores - Prevención
K1 Hongos marinos -  Uso terapéutico - Ensayos
AB The role played by a sustained angiogenesis in cancer and other diseases stimulates theinterest in the search for new antiangiogenic drugs. In this manuscript, we provide evidence that1,8- dihydroxy-9,10-anthraquinone (danthron), isolated from the fermentation broth of the marinefungus Chromolaenicola sp. (HL-114-33-R04), is a new inhibitor of angiogenesis. The results obtainedwith the in vivo CAM assay indicate that danthron is a potent antiangiogenic compound. In vitrostudies with human umbilical endothelial cells (HUVEC) reveal that this anthraquinone inhibitscertain key functions of activated endothelial cells, including proliferation, proteolytic and invasivecapabilities and tube formation. In vitro studies with human breast carcinoma MDA-MB231 andfibrosarcoma HT1080 cell lines suggest a moderate antitumor and antimetastatic activity of thiscompound. Antioxidant properties of danthron are evidenced by the observation that it reduces theintracellular reactive oxygen species production and increases the amount of intracellular sulfhydrylgroups in endothelial and tumor cells. These results support a putative role of danthron as a newantiangiogenic drug with potential application in the treatment and angioprevention of cancer andother angiogenesis-dependent diseases.
PB MDPI
YR 2023
FD 2023-05-15
LK https://hdl.handle.net/10630/27121
UL https://hdl.handle.net/10630/27121
LA eng
NO : Vidal, I.; Torres-Vargas, J.A.; Sánchez, J.M.; Trigal, M.; García-Caballero, M.; Medina, M.Á.; Quesada, A.R. Danthron, an Anthraquinone Isolated from a Marine Fungus, Is a New Inhibitor of Angiogenesis Exhibiting Interesting Antitumor and Antioxidant Properties. Antioxidants 2023, 12, 1101. https://doi.org/10.3390/ antiox12051101
NO Partial funding for open access charge: Universidad de Málaga
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026