RT Conference Proceedings
T1 Raman Optical Activity Monitoring the Interaction of Globular Proteins with Surfactants
A1 Nieto-Ortega, Belén
A1 Hierrezuelo-Osorio, José Manuel
A1 Carnero-Ruiz, Cristóbal
A1 López-Navarrete, Juan Teodomiro
A1 Casado-Cordón, Juan
A1 Ramírez-Aguilar, Francisco Javier
K1 Espectroscopía Raman
AB Protein denaturation by surfactants is related with topic as pharmaceutics, cosmetics, paints or biotechnology. This phenomenon is highly dependent on the physico-chemical properties of the denaturing agents. In this communication we report the ROA spectra of bovine serum albumin in the presence of different surfactants, which share a common hydrophobic tail, with the objerctive of correlating the structural specificities of the surfactant-protein interaction with the ROA signatures by following the protein unfolding process.In our work we propose two new groups of ROA marker bands related with the protein unfolding induced by surfactants. This work represents one of the first applications of ROA to study the interaction of a protein with surfactants, and a new proof of the ability of this chiroptical technique to see beyond that can be seen with conventional Raman spectroscopy.
YR 2014
FD 2014-03-31
LK http://hdl.handle.net/10630/7361
UL http://hdl.handle.net/10630/7361
LA eng
NO Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 24 ene 2026