RT Conference Proceedings
T1 Incidence and type of bicuspid aortic valve in two model species
A1 Fernández-Domínguez, María Carmen
A1 López-García, Alejandro
A1 Soto-Navarrete, María Teresa
A1 Durán-Boyero, Ana Carmen
A1 Fernández-Corujo, Borja
K1 Corazón - Enfermedades
K1 Animales de laboratorio
AB Incidence and type of bicuspid aorticvalve in two model species.MC Fernández 1,2, A López-García 1,2, MT Soto 1,AC Durán 1,2 and B Fernández 1,2.1 Department of Animal Biology, Faculty of Science, University of Málaga, Spain.2 Biomedical Research Institute of Málaga (IBIMA),University of Málaga, Spain.Bicuspid aortic valve (BAV) is the most frequent human congenital cardiac malformation, with an incidence of 1–2% worldwide. Two morphological types exist: type A (incidence  0.75–1.25%) and type B (incidence  0.25–0.5%), each with a distinct aetiology and natural history. Currently, ten animal models of BAV have been described in two different rodent species: one spontaneous Syrian hamster (Mesocricetus auratus) model of BAV type A and nine mutant laboratory mouse (Mus musculus) models of BAV type B. It remains to be elucidated whether the mutations leading to BAV in these models are typespecific or whether there are inter-specific differences regarding the type of BAV that hamsters, mice and humans may develop.To solve this issue, we have characterized the incidence and types of BAVs in four inbred, two outbred and two hybrid lines of Syrian hamsters (n=4,340) and in three inbred, three outbred and one hybrid lines of laboratory mice (n=1,661) by means of stereomicroscopy and scanning electron microscopy. In addition, we have reviewed and calculated the incidence and type of BAVs in the published papers dealing with this anomaly in mice.Our results indicate that the Syrian hamster develops BAVs type A and B including a variety of morphologies comparable to those of humans, whereas the mouse develops only BAVs type B with a short spectrum of valve morphologies. Thus, inter-specific differences between human and mouse aortic valves must be taken into consideration when studying valve disease in murine models.This work was supported by P10-CTS-6068.
PB SAGE Publications Press Ldt
YR 2015
FD 2015
LK http://hdl.handle.net/10630/10729
UL http://hdl.handle.net/10630/10729
LA eng
NO Lab Anim 49 (S3) 2015: 61 (ID:63)
NO Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.   P10-CTS-6068.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026