RT Journal Article
T1 8-oxoguanine DNA glycosylase 1 upregulation as a risk factor for obesity and colorectal cancer
A1 Pilo, Jesús
A1 García-Flores, Libia Alejandra
A1 Clemente-Postigo, María Mercedes
A1 Arranz-Salas, Isabel María
A1 Alcaide, Julia
A1 Ramos-Fernandez, Maria
A1 Lozano-Castro, José
A1 Boughanem Lakhal, Hatim
A1 Kompella, Pallavi
A1 Macías-González, Manuel
K1 Genética
K1 Cáncer colorrectal
K1 ADN - Reparación
K1 Cáncer - Aspectos genéticos
AB DNA damage has been extensively studied as a potentially helpful tool in assessing and preventing cancer, having been widely associated with the deregulation of DNA damage repair (DDR) genes and with an increased risk of cancer. Adipose tissue and tumoral cells engage in a reciprocal interaction to establish an inflammatory microenvironment that enhances cancer growth by modifying epigenetic and gene expression patterns. Here, we hypothesize that 8-oxoguanine DNA glycosylase 1 (OGG1)—a DNA repair enzyme—may represent an attractive target that connects colorectal cancer (CRC) and obesity. In order to understand the mechanisms underlying the development of CRC and obesity, the expression and methylation of DDR genes were analyzed in visceral adipose tissue from CRC and healthy participants. Gene expression analysis revealed an upregulation of OGG1 expression in CRC participants (p < 0.005) and a downregulation of OGG1 in normal-weight healthy patients (p < 0.05). Interestingly, the methylation analysis showed the hypermethylation of OGG1 in CRC patients (p < 0.05). Moreover, expression patterns of OGG1 were found to be regulated by vitamin D and inflammatory genes. In general, our results showed evidence that OGG1 can regulate CRC risk through obesity and may act as a biomarker for CRC.
PB MDPI
YR 2023
FD 2023-03-13
LK https://hdl.handle.net/10630/26851
UL https://hdl.handle.net/10630/26851
LA eng
NO Pilo J, García-Flores LA, Clemente-Postigo M, Arranz-Salas I, Alcaide J, Ramos-Fernandez M, Lozano J, Boughanem H, Kompella P, Macías-González M. 8-Oxoguanine DNA Glycosylase 1 Upregulation as a Risk Factor for Obesity and Colorectal Cancer. International Journal of Molecular Sciences. 2023; 24(6):5488. https://doi.org/10.3390/ijms24065488
NO Partial funding for open access charge: Universidad de Málaga
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026