RT Journal Article
T1 Animal and cellular models of Alzheimer’s disease: Progress, promise, and future approaches.
A1 Trujillo-Estrada, Laura Isabel
A1 Sánchez-Mejías, Elisabeth
A1 Sánchez-Varo, Raquel María
A1 García-León, Juan Antonio
A1 Nuñez-Diaz, Cristina
A1 Dávila-Cansino, José Carlos
A1 Vitorica Ferrández, Javier
A1 LaFerla, Frank
A1 Moreno-González, Inés
A1 Gutiérrez-Pérez, Antonia
A1 Baglietto-Vargas, David
K1 Alzheimer, Enfermedad de - Modelos animales
AB Alzheimer’s disease (AD) is an incurable neurodegenerative disease affecting over 45 million people worldwide. Transgenic mouse models have made remarkable contributions toward clarifying the pathophysiological mechanisms behind the clinical manifestations of AD. However, the limited ability of these in vivo models to accurately replicate the biology of the human disease have precluded the translation of promising preclinical therapies to the clinic. In this review, we highlight several major pathogenic mechanisms of AD that were discovered using transgenic mouse models. Moreover, we discuss the shortcomings of current animal models and the need to develop reliable models for the sporadic form of the disease, which accounts for the majority of AD cases, as well as human cellular models to improve success in translating results into human treatments.
PB SAGE
YR 2022
FD 2022-12-06
LK https://hdl.handle.net/10630/38352
UL https://hdl.handle.net/10630/38352
LA eng
NO Trujillo-Estrada L, Sanchez-Mejias E, Sanchez-Varo R, Garcia-Leon JA, Nuñez-Diaz C, Davila JC, Vitorica J, LaFerla FM, Moreno-Gonzalez I, Gutierrez A, Baglietto-Vargas D. Animal and cellular models of Alzheimer’s disease: Progress, promise, and future approaches. Neuroscientist. 28(6):572-593. 2022
NO https://openpolicyfinder.jisc.ac.uk/id/publication/9526
NO The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Ministerio de Ciencia e Innovacion Grants PID2019-108911RA-100 (DBV) and PID2019-107090RA-100 (IMG); Beatriz Galindo Program BAGAL18/00052 (DBV); Brain and Behaviour Research Foundation NARSAD-27565-2018 (IMG): Ramon y Cajal Program RYC-2017-21879 (IMG); Institute of Health Carlos III (ISCiii) Grants P18/01557 (AG) and P18/01556 (JV), cofinanced by FEDER funds from the European Union; National Institute of Health (NIH) Grant U54-AG054349 (FML); and Junta de Andalucia Consejeria de Economia y Conocimiento Grants UMA18-FEDERJA-211 (AG), US-1262734 (JV), and P18-RT-2233 (AG), cofinanced by Programa Operativo FEDER 2014-2020 and Junta de Andalucia Consejeria de Salud PI-0276-2018 (JAGL).
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026