RT Journal Article
T1 Impact of Foot Surgery and Pharmacological Treatments on Functionality and Pain in Rheumatoid Arthritis: A Five-Year Longitudinal Study
A1 Campos-Cano, Amparo
A1 Castillo-Domínguez, Alejandro
A1 Ortega-Ávila, Ana Belén
A1 Ramos-Petersen, Laura
A1 Gijón-Noguerón, Gabriel
A1 Pérez-Galán, María José
A1 Reinoso-Cobo, Andrés
K1 Artritis reumatoide
K1 Pies - Lesiones y heridas
K1 Farmacología
K1 Cirugía
AB Rheumatoid arthritis (RA) frequently leads to foot deformities,significantly impacting pain, mobility, and quality of life. Surgical and pharmacologicaltreatments are prescribed to manage symptoms, but their long-term effects on foot functionremain unclear. This study evaluates the impact of different treatment approaches, including surgery, methotrexate (MTX), and biological therapy (Bio), on foot functionality andpain progression over five years. Methods: A longitudinal cohort study was conductedwith 103 RA patients classified into five groups: surgery, MTX < 10 years, MTX ≥ 10 years,Bio < 10 years, and Bio ≥ 10 years. Data from 2018 and 2023 were compared using theVisual Analog Scale (VAS), the Manchester Foot Pain and Disability Index (MFPDI), andthe Foot Function Index (FFI). Statistical analyses included ANOVA, Kruskal–Wallis, andROC curve analysis to assess differences between groups and identify key progressionfactors. Results: Patients with ≥10 years of disease duration and non-biological treatment(MTX ≥ 10 years) experienced the most severe deterioration in foot function, with a meanFFI increase of +11.89 points (p < 0.01). In contrast, MTX < 10 years was the only group toshow an improvement in foot function (FFI: −5.29, p = 0.02). The surgery group exhibitedmoderate but highly variable functional changes, while patients on biological therapyshowed less progression in pain and disability compared to their non-biologic counterparts.Hallux abductus valgus severity increased across all groups. Conclusions: Patients withlong-standing RA on non-biologic therapy exhibited the greatest decline in foot function,whereas early treatment with MTX (<10 years of disease duration) appeared to slow deterioration.
PB MDPI
YR 2025
FD 2025-04-25
LK https://hdl.handle.net/10630/38731
UL https://hdl.handle.net/10630/38731
LA eng
NO Campos-Cano A, Castillo-Dominguez A, Ortega-Avila AB, Ramos-Petersen L, Gijon-Nogueron G, Perez-Galan MJ, Reinoso-Cobo A. Impact of Foot Surgery and Pharmacological Treatments on Functionality and Pain in Rheumatoid Arthritis: A Five-Year Longitudinal Study. Healthcare (Basel). 2025 Apr 27;13(9):1004. doi: 10.3390/healthcare13091004. PMID: 40361782; PMCID: PMC12071480.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 21 ene 2026