RT Journal Article
T1 Donepezil alone and combined with intensive language-action therapy on depression and apathy in chronic post-stroke aphasia: A feasibility study
A1 Berthier-Torres, Marcelo Luis
A1 Edelkraut, Lisa
A1 López-González, Francisco Javier
A1 López-Barroso, Diana
A1 Mohr, Bettina
A1 Pulvermüller, Friedemann
A1 Starkstein, Sergio E.
A1 Jorge, Ricardo E.
A1 Torres-Prioris, María José
A1 Dávila-Arias, María Guadalupe
K1 Afasia
K1 Apatia
K1 Logopedia
K1 Neurobiología
K1 Neuropsicofarmacología
K1 Enfermedad cerebrovascular -- Tratamiento
K1 Enfermedad cerebrovascular -- Pacientes -- Rehabilitación
AB This study explored the feasibility and effectiveness of a short-term (10-week) intervention trial using Donepezil administered alone and combined with intensive language action therapy (ILAT) for the treatment of apathy and depression in ten people with chronic post-stroke aphasia. Outcome measures were the Western Aphasia Battery and the Stroke Aphasia Depression Questionnaire-21. Structural magnetic resonance imaging and 18fluorodeoxyglucose positron emission tomography were acquired at baseline and after two endpoints (Donepezil alone and Donepezil-ILAT). The intervention was found to be feasible to implement. Large treatment effects were found. Donepezil alone and combined with ILAT reduced aphasia severity, while apathy and depression only improved with Donepezil-ILAT. Structural and functional neuroimaging data did not show conclusive results but provide hints for future research. Given these overall positive findings on feasibility, language and behavioral benefits, further studies in larger sample sizes and including a placebo-control group are indicated.
PB Elsevier
YR 2022
FD 2022-12-07
LK https://hdl.handle.net/10630/26369
UL https://hdl.handle.net/10630/26369
LA eng
NO Berthier, M. L., Edelkraut, L., López-González, F. J., López-Barroso, D., Mohr, B., Pulvermüller, F., ... & Dávila, G. (2023). Donepezil alone and combined with intensive language-action therapy on depression and apathy in chronic post-stroke aphasia: A feasibility study. Brain and Language, 236, 105205.
NO This work was supported as an independent research grant funded by Pfizer and Eisai. The funders were not involved in the study design, collection, analysis, or interpretation of the data. The work was also supported in part by the Ministerio de Economía, Industria y Competitividad, Instituto de Salud Carlos III, Spain (under Grant: PI16/01514; MLB and GD), and the Junta de Andalucía, Spain (under Grant: P20_00501; GD). MLB has been supported by funds from the European Social Fund (FEDER). LE and FJL-G have been funded by a PhD scholarship from the Spanish Ministry of Education, Culture, and Sport under the FPU program (FPU17/04136; FJL-G: FPU17/04470). DL-B was supported by I + D + i Project Andalusia and European Union Funds (FEDER) (UMA18-FEDERJA-221) and by Ramón y Cajal Program (RYC2020-029495-I) from the Spanish Ministry of Science and Innovation. MT-P has been funded by a postdoctoral fellowship under the program Plan Andaluz de Investigación, Desarrollo e Innovación (PAIDI 2020) (DOC_00421). FP and BM were supported by the Deutsche Forschungsgemeinschaft [Pu 97/15-1 and 15-2 to FP, Mo 697/5-2 to BM]. FP was also supported by the European Research Council [ERC-2019-ADG 883811]  //  Funding for open access charge: Universidad de Málaga / CBUA.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026