RT Conference Proceedings
T1 Direct characterization of functional materials by haptenized fluorescent dendrimers for in vitro allergic drug diagnose
A1 Ruiz-Sanchez, Antonio Jesus
A1 Collado-Martín, Daniel
A1 Mayorga Mayorga, Cristobalina
A1 Torres-Jaén, María Josefa
A1 Pérez-de-Inestrosa-Villatoro, Ezequiel
K1 Dendrímeros
K1 Alergia a los medicamentos
AB β-lactams are the most widely drug prescribed against infections, but they are the most commonlyreported medication allergy too. A correct diagnosis of these allergic reactions is crucial to avoidrejecting them by other more expensive broad-spectrum antibiotics, with potential risk factors for thedevelopment of multiple drug-resistant bacteria. [1] Skin testing is the most consensual approach todiagnose β-lactam allergy, but this in vivo test is not risky free and should be performed under stricthospital surveillance.[2] In vitro testing is not still widely used on account of their low sensitivity. Wereport the use of already haptenized fluorescent dendrimers [3] to control the preparation of materialsfor in vitro test, and their verification by testing on patient sera samples. This fluorescent dendrimer isobtained from a dye with two orthogonal functional groups suitable for click chemistry. [4]Acknowledgments: This work was supported by: MINECO CTQ2016-75870P, Andalusian RegionalMinistry Health (PI-0250-2016); European Regional Development Fund and “Plan Propio Universidadde Málaga” (UMA-Andalucía-TECH).
YR 2020
FD 2020-10-01
LK https://hdl.handle.net/10630/19867
UL https://hdl.handle.net/10630/19867
LA eng
NO Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 21 ene 2026