RT Journal Article
T1 The role of the endocannabinoid system in eating disorders: pharmacological implications
A1 Marco, Eva-María
A1 Romero-Zerbo, Silvana Yanina
A1 Paz Viveros, María
A1 Bermúdez Silva, Francisco Javier
K1 Anorexia nerviosa
K1 Bulimia
AB The endocannabinoid (eCB) system is a widespread intercellular signalling mechanism that plays a critical role in body homoeostasis. It is located in key points involved in food intake and energy expenditure, coordinating all the players involved in energy balance. As such, it has come to be seen as an interesting target for the management of diseases characterized by an imbalanced energy homoeostasis, such as obesity and eating disorders. The aetiology of eating disorders and the molecular systems involved are still largely a mystery. Research has focused on brain circuits where the eCB system plays an important role, such as those related to feeding behaviour and the rewarding properties of food. Accordingly, recent findings have suggested a deregulation of the eCB system in eating disorders. At present, cannabinoid agonists are safe and effective tools in the management of diseases in which weight gain is needed, for example cachexia in AIDS patients. However, studies on the potential therapeutic validity of cannabinoids in eating disorders are scarce and inconclusive. Taken together, all these considerations warrant more preclinical and clinical investigations in the role of the eCB system in eating disorders. Eventually, they may provide novel pharmacological approaches for the treatment of these diseases.
PB Wolters Kluwer Health
YR 2012
FD 2012
LK https://hdl.handle.net/10630/32375
UL https://hdl.handle.net/10630/32375
LA eng
NO Marco, Eva M.a; Romero-Zerbo, Silvana Y.b,c; Viveros, María-Paza; Bermudez-Silva, Francisco J.b,c. The role of the endocannabinoid system in eating disorders: pharmacological implications. Behavioural Pharmacology 23(5 and 6):p 526-536, September 2012. | DOI: 10.1097/FBP.0b013e328356c3c9
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026