RT Journal Article
T1 Synthesis, characterization and biological evaluation of octyltrimethylammonium tetrathiotungstate
A1 Vega-Granados, Karla
A1 Cruz-Reyes, Juan
A1 Horta-Marrón, José F.
A1 Mari-Beffa, Manuel
A1 Díaz-Rubio, Laura
A1 Córdova-Guerrero, Iván
A1 Chávez-Velasco, Daniel
A1 Ocaña Farfán, María del Carmen
A1 Medina-Torres, Miguel Ángel
A1 Romero-Sánchez, Lilian B.
K1 Peces - Embriones
AB Octyltrimethylammonium tetrathiotungstate salt (ATT-C8) was synthesized and its ability to chelate copper was evaluated. The biological and toxic aspects were evaluated by in vitro and in vivo assays, using bovine aorta endothelial cells (BAEC) and zebrafish (Danio rerio) embryos. The obtained results suggest that ATT-C8 has betterbiocompatibility, showing a significantly lower lethal concentration 50 (LC50) value in comparison toammonium tetrathiotungstate (ATT). Zebrafish embryos assay results indicate that both tetrathiotungstatesalts at the studied concentrations increase the hatching time. Even more, an in vivo assay showedthat synthesized materials behave as copper antagonists and have the ability to inhibit its toxicologicaleffects. Also, both materials were found to be active for the in vitro 2,2-diphenyl-1-picrylhydrazyl (DPPH)assay. The characterization of the materials was carried out using the following spectroscopic techniques:Ultraviolet–Visible (UV–Vis), Fourier Transform Infrared (FTIR) and proton nuclear magnetic resonance (1H-NRM).
PB Springer Nature
YR 2021
FD 2021
LK https://hdl.handle.net/10630/23659
UL https://hdl.handle.net/10630/23659
LA eng
NO Biometals 34(1): 107-117, 2021
NO The authors gratefully acknowledge the financial support provided by the UABC-UNAM SENERCONACYT117373 project. Authors thank David Navas Fernandez for excellent technical support in these experiments, as well as Dr. Raúl Romero Rivera for his valuable comments. The scientific work developed by MAM’s group is supported by grants PID2019-105010RB-I00 (Spanish Ministry of Science, Innovation and Universities), and UMA18- FEDERJA-220 (Andalusian Government and FEDER) and funds from group BIO 267 (Andalusian Government), as well as funds from ‘‘Plan Propio de Investigación y Transferencia’’ (U. Málaga).
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026