RT Journal Article
T1 Genomic variants association with selective hypersensitivityreactions to amoxicillin and clavulanic acid
A1 Nuñez, Rafael
A1 Fernández-Santamaría, Rubén
A1 Salas, María
A1 Bogas, Gador
A1 Diez-Echave, Patricia
A1 Mayorga Mayorga, Cristobalina
A1 Torres-Jaén, María Josefa
A1 Fernández-Duarte, Tahía Diana
K1 Alergia
AB In summary, there are rare variants found in our patients that could be related to the development of AX or CLV- induced IDHRs. Interestingly, some of these rare variants could be associated with selective response to AX, such as the proapoptotic endonuclease ENDOG and neutrophil degranulation pathway, previously associ- ated with drug- induced anaphylaxis,6 or to CLV, like immunoprote- asome component PSMD8. Differences could be related to nature and metabolic characteristics of each drug; however, more research is needed. These findings represent a first step to identify potential genetic biomarkers to predict the susceptibility of suffering AX and CLV IDHRs.
PB Wiley
YR 2024
FD 2024-06-29
LK https://hdl.handle.net/10630/31960
UL https://hdl.handle.net/10630/31960
LA eng
NO Nuñez, R., Fernandez-Santamaria, R., Salas, M., Bogas, G., Diez-Echave, P., Mayorga, C., Torres, M.J. and Fernandez, T.D. (2024), Genomic variants association with selective hypersensitivity reactions to amoxicillin and clavulanic acid. Allergy.
NO This work has been supported by Institute of Health ‘Carlos III’ (ISCIII) of the Ministry of Economy and Competitiveness (MINECO), (grants co- funded by European Regional Development Fund: PI15/01206, PI17/01237, PI18/00095, PI20/01734, PI21/0329, RETICS ARADYAL RD16/0006/0001, RICORS REI, RD21/0002/0008); Andalusian Regional Ministry of Health (grants PI- 0241- 2016, PE- 0172- 2018, PI- 0127- 2020). GB is a Clinical Investigator (B- 0007- 2022) re- search contract by Andalusian Regional Ministry Health. PDE holds a Sara Borrell research contract by Institute of Health ‘Carlos III’ (CD22/00112). CM holds a ‘Nicolas Monardes’ research contract by Andalusian Regional Ministry Health (RC- 0004- 2021). Funding for open access charge: Univesidad de Malaga/CBUA.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 24 ene 2026