RT Conference Proceedings
T1 Analyzing plant stress granules in response to plant viruses
A1 Krenz, Björn
K1 Virus
AB Plant viruses have the ability to redirect host machineries and processes to establish a productive infection. Virus-host interactions lead to the reprogramming of the plant cell cycle and transcriptional controls, inhibition of cell death pathways, interference with cell signaling and protein turnover, and suppression defense pathways. Stress granules (SGs) are structures within cells that regulate gene expression during  stress response, e.g. viral infection. In mammalian cells assembly of SGs is dependent on the Ras-GAP SH3-domain–binding protein (G3BP). The C-terminal domain of the viral nonstructural protein 3 (nsP3) of Semliki Forest virus (SFV) forms a complex with mammalian G3BP and sequesters it into viral RNA replication complexes in a manner that inhibits the formation of SGs. The binding domain of nsP3 to HsG3BP was mapped to two tandem ‘FGDF’ repeat motifs close to the C-terminus of the viral proteins. It was speculated that plant viruses employ a similar strategy to inhibit SG function.
YR 2018
FD 2018-12-10
LK https://hdl.handle.net/10630/17011
UL https://hdl.handle.net/10630/17011
LA eng
NO Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.Vicerrectorado de Investigación y Programa de doctorado "Biotecnología Avanzada"
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026