RT Journal Article
T1 Cognitive reserve mediates the severity of certain neuropsychological deficits related to cocaine use disorder
A1 Vicario, Selene
A1 Pérez-Rivas, Aroa
A1 Ladrón de Guevara-Miranda, David
A1 Santín-Núñez, Luis Javier
A1 Sampedro-Piquero, Patricia
K1 Adicción
K1 Memoria
K1 Atención
AB The concept of cognitive reserve (CR) is being considered in the field of substance use disorder (SUD) by observing that there are individuals whose brain alterations are not related to the cognitive symptomatology they present. Our aims were to characterise the possible neuropsychological deficits in a sample of subjects with SUD compared to healthy controls and to determine whether the degree of CR is a mediator in the cognitive functioning of these patients. To perform these objectives, the study involved a sample of subjects with SUD in outpatient treatment and a healthy control group. A CR questionnaire and a comprehensive neuropsychological assessment were administered, and we also collected data related to drug consumption and psychological well-being. The SUD group showed poorer performance compared to the control group in several cognitive domains (attention, declarative memory, executive functions and emotional perception), as well as in psychological comfort. Interestingly, we observed that the deficits found in attention and processing speed were highly mediated by the CR level of the participants, an effect that we did not observe in the rest of the variables registered. Our results suggest that long-term drug consumption leads to cognitive deficits and affects the psychological well-being of the subjects. Moreover, the CR should be taken into account during the assessment and rehabilitation of patients with SUD due to its protective role against certain neuropsychological deficits.
PB Elsevier
YR 2020
FD 2020-08
LK https://hdl.handle.net/10630/23838
UL https://hdl.handle.net/10630/23838
LA eng
NO Vicario, S., Pérez-Rivas, A., de Guevara-Miranda, D. L., Santín, L. J., & Sampedro-Piquero, P. (2020). Cognitive reserve mediates the severity of certain neuropsychological deficits related to cocaine use disorder. Addictive Behaviors, 107, 106399. https://doi.org/10.1016/J.ADDBEH.2020.106399
NO Author manuscript
NO This study was funded by grants from the Spanish Ministry of Economy and Competitiveness (MINECO, Agencia Estatal de Investigación) cofounded by the European Research Development Fund -AEI/FEDER, UE- (PSI2017-82604-R to L.J.S.), and from University of Málaga (Plan Propio 2017 – ‘Ayudas para el fomento de proyectos de investigación en Ciencias Sociales y Jurídicas, Humanidades, Arquitectura y Bellas Artes’– AYUDA_18_B.3._10 to P.S.P.). The authors P.S-P. and D.L.G-M. hold postdoctoral contracts from University of Malaga (Ayuda para la Incorporación de Doctores del Plan Propio de la Universidad de Málaga (A.4) and Contrato postdoctoral del Plan Propio de la Universidad de Málaga (A.3), respectively). The author A.P-R holds a grant from University of Malaga (Ayuda para la iniciación a la investigación del Plan Propio de la Universidad de Málaga (A.1)).
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 24 ene 2026